15 documents found, page 1 of 2
Integrated Use of Bioaccumulation, Genotoxic, and Haematological Endpoints to A...
Mieiro, Cláudia Leopoldina; Coelho, João; Reis, Ana; Castro, Diana; Figueira, Paula; Martinho, Filipe; Pardal, Miguel; Pereira, Eduarda; Pacheco, MárioBiosorption successfully remediates saline water contaminated with legacy contaminants, but its effects on the health of marine organisms remain unclear. Therefore, our aim was to address this knowledge gap with data on the accumulation ability, as well as the cytogenetic and biochemical effects in turbot (Scophthalmus maximus). To this end, we exposed turbot for seven days to a mixture of remediated metals (Re...
High-Throughput Drug Screening Revealed That Ciclopirox Olamine Can Engender Ga...
Pádua, Diana; Figueira, Paula; Pinto, Mariana; Maia, André Filipe; Peixoto, Joana; Lima, Raquel T; Pombinho, António; Pereira, Carlos FilipeCancer stem cells (CSCs) are relevant therapeutic targets for cancer treatment. Still, the molecular circuits behind CSC characteristics are not fully understood. The low number of CSCs can sometimes be an obstacle to carrying out assays that explore their properties. Thus, increasing CSC numbers via small molecule-mediated cellular reprogramming appears to be a valid alternative tool. Using the SORE6-GFP repor...
Integrated Use of Bioaccumulation, Genotoxic, and Haematological Endpoints to A...
Mieiro, Cláudia; Coelho, João; Reis, Ana Teresa; Castro, Diana; Figueira, Paula; Martinho, Filipe; Pardal, Miguel; Pereira, Eduarda; Pacheco, MárioBiosorption successfully remediates saline water contaminated with legacy contaminants, but its effects on the health of marine organisms remain unclear. Therefore, our aim was to address this knowledge gap with data on the accumulation ability, as well as the cytogenetic and biochemical effects in turbot (Scophthalmus maximus). To this end, we exposed turbot for seven days to a mixture of remediated metals (Re...
Removal of mercury by silica-supported ionic liquids: efficiency and ecotoxicol...
Viana, Thainara; Almeida, Raquel; Figueira, Paula; Rocha, Luciana; Neves, Márcia; Freitas, Rosa; Freire, Mara; Henriques, Bruno; Pereira, EduardaAnthropogenic impacts have affected the coastal environment and contributed to its contamination. Mercury (Hg) is widespread in nature and has been shown to be toxic in even the smallest amounts, negatively affecting not only the marine ecosystem but also the entire trophic chain due to its biomagnification. Mercury ranks third on the Agency for Toxic Substances and Diseases Registry (ATSDR) priority list and i...
HMGA1 Has Predictive Value in Response to Chemotherapy in Gastric Cancer
Pádua, Diana; Pinto, Débora Filipa; Figueira, Paula; Pereira, Carlos Filipe; Almeida, Raquel; Mesquita, PatríciaGastric cancer is a serious health problem worldwide. Although its incidence is decreasing, the five-year survival rate remains low. Thus, it is essential to identify new biomarkers that could promote better diagnosis and treatment of patients with gastric cancer. High-mobility group AT-hook 1 (HMGA1) is a non-histone, chromatin-binding protein that has been found overexpressed in several tumor types. It has be...
A Single Digestion Procedure for Determination of Major, Trace, and Rare Earth ...
Carvalho, Lina; Reis, Ana T.; Soares, Eugénio; Tavares, César; Monteiro, Rui J.R.; Figueira, Paula; Henriques, Bruno; Vale, Carlos; Pereira, EduardaThe simultaneous determination of major, trace, and rare earth elements in sediments requires the development of specific procedures to prevent interfer- ences. A single digestion method adapted from the EPA method 3051A is proposed for the quantification of 42 elements in sediments by inductively coupled plasma techniques associated with optical emission spectroscopy (ICP-OES) and mass spectrometry (ICP- MS). ...
Simultaneous removal of trace elements from contaminated waters by living Ulva ...
Henriques, Bruno; Teixeira, Ana; Figueira, Paula; Reis, Ana T.; Almeida, Joana; Vale, Carlos; Pereira, EduardaThis work shows the capabilities of living seaweed, Ulva lactuca, to remove As, Cd, Pb, Cu, Cr, Hg, Mn and Ni from contaminated waters. Experiments were performed with three algal doses (1.5, 3.0 and 6.0 g L-1, FW), two ionic strengths (salinity 15 and 35), and trace element concentrations corresponding to the maximum allowed values in wastewaters. The highest removals were obtained with the algal dose of 6 g L...
Evidence for contrasting accumulation pattern of cadmium in relation to other e...
Catry, Teresa; Figueira, Paula; Carvalho, Lina; Monteiro, Rui J. R.; Coelho, Pedro Duarte; Lourenço, Pedro Miguel; Catry, Paulo; Tchantchalam, QuintinoShellfish harvesting in intertidal areas is a widespread and economically important activity in many countries across West Africa. However, in some areas, there is virtually no information concerning the levels of contaminants (and other elements related to nutritional aspects) in the harvested species. We collected sediments and several individuals of the West African bloody cockle Senilia senilis and of the r...
Major, minor, trace and rare earth elements in sediments of the Bijagós archipe...
Carvalho, Lina; Figueira, Paula; Monteiro, Rui J. R.; Reis, Ana Teresa; Almeida, Joana C.; Catry, Teresa; Lourenço, Pedro Miguel; Catry, PauloSixty sediment samples from four sites in the Bijagós archipelago were characterized for fine fraction, loss on ignition, major, minor and trace elemental composition (Al, Fe, Ca, Mg, Ti, P, Zr, Mn, Cr, Sr, Ba, B, V, Li, Zn, Ni, Pb, As, Co, U, Cu, Cs and Cd), and the elements of the La–Lu series. Element concentrations were largely explained by the Al content and the proportion of fine fraction content, with th...
Bioaccumulation of Hg, Cd and Pb by Fucus vesiculosus in single and multi-metal...
Henriques, Bruno; Lopes, Cláudia Batista; Figueira, Paula; Rocha, Luciana S.; Duarte, Armando C.; Vale, Carlos; Pardal, Miguel A.; Pereira, EduardaResults of 7-days exposure to metals, using environmentally realistic conditions, evidenced the high potential of living Fucus vesiculosus to remove Pb, Hg and Cd from contaminated salt waters. For different contamination scenarios (single- and multi-contamination), ca 450 mg L-1 (dry weight), enable to reduce the concentrations of Pb in 65%, of Hg in 95% and of Cd between 25 and 76%. Overall, bioconcentration ...