60 documents found, page 1 of 6
Inovação em saúde e o seu impacto na performance financeira dos hospitais: uma ...
Neves, Margarida CorreiaEsta dissertação estuda a relação entre a inovação e impacto financeiro nos hospitais, com o objetivo de averiguar o estado da arte e identificar as lacunas na literatura que possam ser investigadas em estudos futuros. A metodologia utilizada na realização deste trabalho foi a revisão sistemática de literatura, a qual permite reunir e discutir um conjunto considerável de publicações e resultados pertinentes sob...
Sorting nexin 3 mutation impairs development and neuronal function in Caenorhab...
Vieira, Neide; Bessa, Carlos; Rodrigues, Ana J.; Marques, Paulo; Chan, Fung-Yi; Carvalho, Ana Xavier de; Neves, Margarida Correia; Sousa, NunoThe sorting nexins family of proteins (SNXs) plays pleiotropic functions in protein trafficking and intracellular signaling and has been associated with several disorders, namely Alzheimer's disease and Down's syndrome. Despite the growing association of SNXs with neurodegeneration, not much is known about their function in the nervous system. The aim of this work was to use the nematode Caenorhabditis elegans ...
Toxoplasmosis-associated IRIS involving the CNS: a case report with longitudina...
Silva, Rita Catarina Assunção Ribeiro; Nóbrega, Cláudia; Reiriz, Eugénia; Almeida, Soraia; Castro, Rui Manuel Rosário Sarmento; Neves, Margarida CorreiaBackground: HIV-infected patients may present an unforeseen clinical worsening after initiating antiretroviral therapy known as immune reconstitution inflammatory syndrome (IRIS). This syndrome is characterized by a heightened inflammatory response toward infectious or non-infectious triggers, and it may affect different organs. Diagnosis of IRIS involving the central nervous system (CNS-IRIS) is challenging du...
Effect of blood type on anti-a-Gal immunity and the incidence of infectious dis...
Neves, Margarida CorreiaThe identification of factors affecting the susceptibility to infectious diseases is essential toward reducing their burden on the human population. The ABO blood type correlates with susceptibility to malaria and other infectious diseases. Due to the structural similarity between blood antigen B and Gal alpha 1-3Gal beta 1-(3)4GlcNAc-R (alpha-Gal), we hypothesized that self-tolerance to antigen B affects the i...
Tuberculosis among the homeless: should we change the strategy?
Dias, M.; Gaio, R.; Sousa, P.; Abranches, M.; Gomes, M.; Oliveira, O.; Neves, Margarida Correia; Ferreira, E.; Duarte, R.BACKGROUND: Tuberculosis (TB) is a major concern among high-risk populations such as the homeless. OBJECTIVES: To evaluate TB incidence and treatment outcomes among homeless patients in Portugal and to identify predictors of unsuccessful TB treatment outcomes among the homeless. DESIGN: This was a retrospective cohort study of all TB patients notified in Portugal from 2008 to 2014. Characteristics of homeless T...
How age, sex and genotype shape the stress response
Novais, Ashley Cruz; Monteiro, Susana; Roque, Susana; Neves, Margarida Correia; Sousa, NunoExposure to chronic stress is a leading pre-disposing factor for several neuropsychiatric disorders as it often leads to maladaptive responses. The response to stressful events is heterogeneous, underpinning a wide spectrum of distinct changes amongst stress-exposed individuals'. Several factors can underlie a different perception to stressors and the setting of distinct coping strategies that will lead to indi...
Microfluidic immunosensor for rapid and highly-sensitive salivary cortisol quan...
Pinto, Vânia C.; Sousa, Paulo J.; Catarino, Susana Oliveira; Neves, Margarida Correia; Minas, GraçaThis paper presents a novel poly(dimethylsiloxane) (PDMS) microfluidic immunosensor that integrates a complementary metal-oxide-semiconductor (CMOS) optical detection system for a rapid and highly-sensitive quantification of salivary cortisol. The simple and non-invasive method of saliva sampling provides an interesting alternative to the blood, allowing a fast sampling at short intervals, relevant for many cli...
The choroid plexus in health and in disease: dialogues into and out of the brain
Marques, Fernanda; Sousa, João Carlos; Brito, Maria Alexandra; Pahnke, Jens; Santos, Cecilia; Neves, Margarida Correia; Palha, Joana AlmeidaThis article brings the choroid plexus into the context of health and disease. It is remarkable that the choroid plexus, composed by a monolayer of epithelial cells that lie in a highly vascularized stroma, floating within the brain ventricles, gets so little attention in major physiology and medicine text books and in the scientific literature in general. Consider that it is responsible for producing most of t...
Prevalence and factors associated with diabetes mellitus among tuberculosis pat...
Costa, João Cordeiro da; Oliveira, Olena Radomska; Baía, Luís; Gaio, Rita; Neves, Margarida Correia; Duarte, RaquelIn Press, Corrected Proof; The association between diabetes mellitus (DM) and tuberculosis (TB) has been a matter of study worldwide, since it is assumed that DM triples the risk of TB. Recent studies have found discrepant prevalence of DM among TB patients, ranging from 5.3% in Denmark to 44% in India. There is an urgent need to control both epidemics in order to achieve the World Health Organization (WHO) TB ...
Adult body height is a good predictor of different dimensions of cognitive func...
Pereira, Vitor H.; Costa, Patrício Soares; Santos, Nadine Correia; Cunha, Pedro; Neves, Margarida Correia; Palha, Joana Almeida; Sousa, NunoBackground: Adult height, weight, and adiposity measures have been suggested by some studies to be predictors of depression, cognitive impairment, and dementia. However, the presence of confounding factors and the lack of a thorough neuropsychological evaluation in many of these studies have precluded a definitive conclusion about the influence of anthropometric measures in cognition and depression. In this stu...