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Vulvovaginal candidiasis and asymptomatic vaginal colonization in Portugal: Epi...

Fernandes, Ângela; Azevedo, Nuno Miguel Morais; Valente, Andreia; Dias, Marisol; Gomes, Ana; Nogueira-Silva, Cristina; Henriques, Mariana

Vulvovaginal candidiasis (VVC) has been identified as a global issue of concern due to its clinical, social and economic implications. The emerging relevance of VVC makes it crucial to increase the knowledge on its epidemiological and etiological features in order to improve its prevention and treatment. Thus, this study aimed to reveal the incidence, microbiology, antifungal pattern and risk factors of VVC in ...


Hormones modulate Candida vaginal isolates biofilm formation and decrease their...

Gonçalves, Bruna Fernandes; Azevedo, Nuno Miguel Morais; Henriques, Mariana; Silva, Sónia Carina

Published Ahead-of-Print: 29 June 2019; Vulvovaginal candidiasis (VVC) is an infection usually caused by Candida albicans and increasingly by Candida glabrata, which has an intrinsically high resistance to commonly used antifungals. Candida species possess virulence factors that contribute to VVC development, as the ability to form biofilms in vaginal walls and intrauterine devices. It is known that VVC is prom...


Transcriptional responses of Candida glabrata biofilm cells to fluconazole are ...

Alves, R.; Kastora, Stavroula L.; Gomes-Gonçalves, Alexandra; Azevedo, Nuno Miguel Morais; Rodrigues, Célia F.; Silva, Sónia Carina; Demuyser, Liesbeth

The datasets generated in this study are available at public repositories or from the corresponding author upon request. The raw RNA-seq data in fastq format, as well as the processed data have been deposited in NCBI’s Gene Expression Omnibus and are accessible through GEO Series accession number GSE121074.; Candida glabrata is an important human fungal pathogen known to trigger serious infections in immune-com...


Antisense therapy to control adhesion and filamentation of Candida albicans

Azevedo, Nuno Miguel Morais

Dissertação de mestrado integrado em Biomedical Engineering; The incidence of fungal infections has increased significantly in the last years, contributing to the augment of morbidity and mortality in health care system. A raise in antimicrobial resistance, the number of immunosuppressive patients and the restricted number of antifungal drugs are the most common causes of these infections, where Candida species...


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