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Leishmania amazonensis-induced caMP triggered by adenosine a2B receptor is impo...
Figueiredo, Amanda Braga de; Testasicca, Miriam Conceição de Souza; Mineo, Tiago Wilson Patriarca; Afonso, Luís Carlos CroccoDifferently from others Leishmania species, infection by the protozoan parasite L. amazonensis is associated with a lack of antigen-specific T-cell responses. Dendritic cells (DC) are essential for the innate immune response and for directing the differentiation of T-helper lymphocytes. Previously, we showed that L. amazonensis infection impairs DC activation through the activation of adenosine A2B receptor, an...
Purinergic signaling and infection by Leishmania : a new approach to evasion of...
Figueiredo, Amanda Braga de; Testasicca, Miriam Conceição de Souza; Afonso, Luís Carlos CroccoInfection by protozoan parasites is part of the most common Tropical Neglected Diseases. In the case of leishmaniasis, several millions of people are at risk of contracting the disease. In spite of innumerous studies that elucidated the immune response capable of killing the parasite, the understanding of the evasion mechanisms utilized by the parasite to survive within the very cell responsible for its destruc...
Recrutamento do receptor de adenosina A2B e ativação da via de AMPc- PI3K-ERK1/...
Figueiredo, Amanda Braga deTese (Doutorado em Ciências Biológicas) - Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, 2016.; A infecção por Leishmania pode resultar num amplo espectro de manifestações clínicas e a infecção por Leishmania amazonensis é associada a uma deficiência na resposta de linfócitos T específicos para o parasito. Células dendríticas direcionam a diferenciação de linfócitos ...
Ecto-nucleotidase activities of promastigotes from leishmania (Viannia) brazili...
Leite, Pauline Martins; Gomes, Rodrigo Saar; Figueiredo, Amanda Braga de; Serafim, Tiago Donatelli; Tafuri, Wagner Luiz; Gomes, Carolina CavaliériBackground: Leishmania (Viannia) braziliensis has been associated with a broad range of clinical manifestations ranging from a simple cutaneous ulcer to destructive mucosal lesions. Factors leading to this diversity of clinical presentations are not clear, but parasite factors have lately been recognized as important in determining disease progression. Given the fact that the activity of ecto-nucleotidases corr...
Leishmania metacyclogenesis is promoted in the absence of purines.
Serafim, Tiago Donatelli; Figueiredo, Amanda Braga de; Costa, Pedro Augusto Carvalho; Silva, Eduardo de Almeida Marques da; Gonçalves, RicardoLeishmania parasites, the causative agent of leishmaniasis, are transmitted through the bite of an infected sand fly. Leishmania parasites present two basic forms known as promastigote and amastigote which, respectively, parasitizes the vector and the mammalian hosts. Infection of the vertebrate host is dependent on the development, in the vector, of metacyclic promastigotes, however, little is known about the ...
Leishmania amazonensis prejudica resposta de células dendríticas via inibição d...
Figueiredo, Amanda Braga deInfecções por Leishmania podem resultar num amplo espectro de manifestações clínicas, e o resultado da doença é determinado pela espécie do parasito e a resposta imune do hospedeiro. Células dendríticas desempenham um papel essencial na modulação da resposta imune, incluindo durante a infecção por Leishmania. O ATP extracelular exibe propriedades pró-inflamatórias, enquanto a adenosina é um importante mediador ...
Extracellular nucleotide metabolism in Leishmania : influence of adenosine in t...
Silva, Eduardo de Almeida Marques da; Oliveira, Jamile Camargos de; Figueiredo, Amanda Braga de; Lima Júnior, Djalma de Souza; Carneiro, Cláudia MartinsLeishmaniasis is a parasitic disease with a variety of clinical forms, which are related to the Leishmania species involved. In the murine model, Leishmania amazonensis causes chronic non-healing lesions in Leishmania braziliensis- or Leishmania major-resistant mouse strains. In this study, we investigated the involvement of the pathway of extracellular nucleotide hydrolysis, with special focus on the role of e...