19 documents found, page 1 of 2
Pros and Against of hormonal contraception
Castel-Branco, M.; Figueiredo, I. V.Many benefits of the contraceptive pill are recognized in healthy women: regular cycles, without heavy bleeding, without dysmenorrhea and without premenstrual syndrome. But the contraceptive pill can be used for specific therapeutic objectives: treatment of polycystic ovaries, endometriosis, vaginal bleeding disorders and in long term acne, seborrhea, hirsutism and alopecia therapy (contraceptive pills containi...
Potential herb-drug interactions found in a community pharmacy patients
Batista, C.; Pinho, C.; Castel-Branco, M. M.; Caramona, M. M.; Figueiredo, I. V.Phytotherapy has always played a leading role in therapeutics. However, a strong knowledge of the risk-benefit relationship of herbal products by patients and health professionals is necessary. The goals of this study were to characterize the consumption pattern of medicinal plants in patients in a community pharmacy, identify potential herb-drug interactions, and establish a list of recommendations for health ...
Medication follow-up in type 2 diabetes patients at a primary health care center
Figueiredo, I. V.; Móteiro, C.; Castel-Branco, M. M.; Caramona, M. M.; Fernandez-Llimos, F.Objetivo: Evaluar el impacto de un programa de seguimiento farmacoterapéutico de pacientes con diabetes mellitus en un centro de salud, mediante la evaluación de los resultados clínicos y humanísticos. Método: Estudio de intervención sobre una cohorte de pacientes en seguimiento farmacoterapéutico entre octubre 2011 y julio 2012. El médico de familia seleccionó todos los pacientes atendidos en el centro con dia...
Efeito da adesão à terapêutica no estado de saúde do idoso
Mosca, C.; Castel-Branco, M. M.; Caramona, M. M.; Figueiredo, I. V.The prevalence of chronic diseases increases with age, and the constant growth of the overall population makes adherence to therapy a major challenge. A solution to the problem of non-adherence to therapy prescribed by the physician population is the implementation, in community pharmacy, of stock monitoring and pharmacist intervention. We evaluated 54 elderly patients treated with at least 3 drugs with an auto...
Procedimentos Operativos Normalizados para pesquisa de informação clínica sobre...
Abrantes, C.; Rama, A. C.; Caramona, M. M.; Meliço-Silvestre, A.; Fernandez-Llimos, F.; Figueiredo, I. V.Information related to adverse effects of antiretroviral therapy can determine non-compliance and future therapeutic options. Evidence based practice includes a focalized clinical question to obtain the better information assessed by the parameters sensitivity and specificity. The main purpose of the work is the optimization of a systematic methodology of research clinical information about adverse effects of a...
Necessidades reais de implementação de novos serviços farmacêuticos centrados n...
Castel-Branco, M. M.; Caramona, M. M.; Fernandez-Llimos, F.; Figueiredo, I. V.While new more potent and complex pharmaceutical agents are becoming available, increasing demands on doctors and the health care system, the increase of drug related morbidity and mortality throughout the world and rising costs related with the incorrect use of medicines make it clear that the identification of a practitioner who is available to focus on the management of all of a patient’s medicines would be ...
Correlation between total nitrite/nitrate concentrations and monoamine oxidase ...
Nunes, S. F.; Figueiredo, I. V.; Pereira, J. S.; Lopes, M. C.; Caramona, MargaridaThe aim of this study was to determine the correlation between total nitrite/nitrate concentrations (NOx) and the kinetic parameters of monoamine oxidase enzymes (MAO-A and MAO-B) and semicarbazide-sensitive amine oxidase (SSAO) in human mesenteric arteries. Arteries were from non-diabetic and type 2 diabetic patients with sigmoid or rectum carcinoma for whom surgery was the first option and who were not expose...
Monoamine oxidase and semicarbazide-sensitive amine oxidase kinetic analysis in...
Nunes, S. F.; Figueiredo, I. V.; Pereira, João; Lemos, E. T.; Reis, F.; Teixeira, F.; Caramona, M. M.Monoamine oxidase (MAO, type A and B) and semicarbazide-sensitive amine oxidase (SSAO) metabolize biogenic amines, however, the impact of these enzymes in arteries from patients with type 2 diabetes remains poorly understood. We investigated the kinetic parameters of the enzymes to establish putative correlations with noradrenaline (NA) content and patient age in human mesenteric arteries from type 2 diabetic p...
The maximal electroshock seizure (MES) model in the preclinical assessment of p...
Castel-Branco, M. M.; Alves, G. L.; Figueiredo, I. V.; Falcão, Amílcar; Caramona, M. M.The choice of appropriate animal models for the initial in vivo testing of potential anticonvulsant compounds is one of the most important steps in the successful search for new antiepileptic drugs. The purpose of this paper is to describe the most important aspects to take into account when performing the maximal electroshock seizure (MES) test in the routine laboratory screening of new antiepileptics: the con...
Lamotrigine pharmacokinetic/pharmacodynamic modelling in rats
Castel-Branco, M. M.; Falcão, A. C.; Figueiredo, I. V.; Caramona, M. M.The aim of this study was to perform a pharmacokinetic/pharmacodynamic (PK/PD) modelling of lamotrigine following its acute administration to rats. Adult male Wistar rats were given 10 mg/kg of lamotrigine intraperitoneally. Plasma and brain samples were obtained at predetermined times over 120 h post-dose and analysed by liquid chromatography. The anticonvulsant profile against maximal electroshock seizure sti...