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Alanyl-glutamine attenuates 5-fluorouracil-induced intestinal mucositis in apol...

Araújo, C.V.; Lazzarotto, Cícera Regina; Aquino, Cristhyane Costa de; Figueiredo, Italo L.; Costa, Tiê Bezerra; Alves, L. A. de Oliveira

Apolipoprotein E (APOE=gene, apoE=protein) is a known factor regulating the inflammatory response that may have regenerative effects during tissue recovery from injury. We investigated whether apoE deficiency reduces the healing effect of alanyl-glutamine (Ala-Gln) treatment, a recognized gut-trophic nutrient, during tissue recovery after 5-FU-induced intestinal mucositis. APOE-knockout (APOE-/-) and wild-type ...

Date: 2016   |   Origin: Oasisbr
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