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The role of actigraphy in the assessment of central disorders of Hypersomnolenc...
Maia, Susana; Soares, Joana Isabel; Borges, Daniel Filipe; Lopes, João Casalta; Gonçalves, Marta; Borges, Daniel FilipeActigraphy provides an objective measure of sleepiness and is recommended by the American Academy of Sleep Medicine for use 7–14 days prior to multiple sleep latency testing. It plays a valuable role in the differential diagnosis of hypersomnolence. Our aim was to provide a comprehensive summary of actigraphy features in central disorders of hypersomnolence (CDH). Data were sourced from six bibliographic databa...
Choroidal Melanoma
Coutinho, Inês; Teixeira, Tânia; Simões, Paulo César; Lopes, João Casalta; Borrego, Margarida; Fernandes, Júlia; Cabral, João; Prieto, IsabelChoroidal melanoma is the most common primary intraocular malignant tumor in adults. None of the different treatments available offers advantages of survival, resorting more and more to conservative treatments such as brachytherapy, which has been available in Portugal since 2013. In this article we review the clinical characteristics, risk factors, diagnosis, complementary exams and therapeutic options in chor...
Health Care Associated Multidrug-Resistant Bacteria in a Pediatric Hospital: Fi...
Mação, Patrícia; Lopes, João Casalta; Oliveira, Henrique; Oliveira, Guiomar; Rodrigues, FernandaIntroduction: In recent years there has been an increase of infections caused by multidrug-resistant bacteria. Paediatric data are scarce, particularly at national level.Aims: To analyse trends of health-care associated multidrug-resistant bacteria infections in a paediatric hospital.Material and Methods: A retrospective incidence study was conducted in medical, surgical and intensive care wards in a level III ...
Beyond the limits of oxygen: effects of hypoxia in a hormone-independent prosta...
Mamede, AC; Abrantes, Ana M; Pedrosa, L; Lopes, João Casalta; Pires, A S; Teixo, R J; Gonçalves, A C; Ribeiro, A B Sarmento; Maia, C J; Botelho, M FProstate cancer (PCa) has a high incidence worldwide. One of the major causes of PCa resistance is intratumoral hypoxia. In solid tumors, hypoxia is strongly associated with malignant progression and resistance to therapy, which is an indicator of poor prognosis. The antiproliferative effect and induced death caused by doxorubicin, epirubicin, cisplatin, and flutamide in a hormone-independent PCa cell line will...