O Diabetes mellitus (DM) é uma doença metabólica de etiologia múltipla, caracterizada por uma hiperglicemia decorrente de uma alteração na secreção ou ação da insulina. O DM tipo 1 (DM1) está relacionado com a deficiência de insulina resultante da destruição das células-β do pâncreas; o DM tipo 2 (DM2) resulta de um processo fisiopatológico que culmina com a resistência à insulina, sendo o DM2 considerado um pr...
Background Myelodysplastic syndromes are heterogeneous disorders. Patients with myelodysplastic syndrome disease often have ineffective hematopoiesis, cytopenias, blood cell dysplasia in one or more cell types, and are at high risk for developing acute myeloid leukemia. In myelodysplastic syndrome, mutations of TP53 gene are usually associated with complex karyotype and confer a worse prognosis. In the present ...
Objective/background: Sickle-cell anemia (SCA) is a genetic blood disease characterized by chronic inflammation and a heterogeneous clinical picture. Serum tumor necrosis factor (TNF-alpha) and interleukin 10 (IL-10) levels are associated with the clinical course of SCA. This study aimed to evaluate the association between the frequency of the polymorphisms TNF- alpha-308 G ? A, IL-10-1082 G ? A, IL-10-819 C ? ...