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Avaliação do risco de desenvolver diabetes mellitus tipo 2 em estudantes do cur...

Figueiredo, Monalisa Feliciano; Maia Filho, Pedro Aurio; Almeida Filho, Tarcísio Paulo de; Laurentino, Marília Rocha; Barbosa, Maritza Cavalcante

O Diabetes mellitus (DM) é uma doença metabólica de etiologia múltipla, caracterizada por uma hiperglicemia decorrente de uma alteração na secreção ou ação da insulina. O DM tipo 1 (DM1) está relacionado com a deficiência de insulina resultante da destruição das células-β do pâncreas; o DM tipo 2 (DM2) resulta de um processo fisiopatológico que culmina com a resistência à insulina, sendo o DM2 considerado um pr...

Date: 2021   |   Origin: Oasisbr

Presence of new mutations in the TP53 gene in patients with low-risk myelodyspl...

Duarte, Fernando Barroso; Lemes, Romélia Pinheiro Gonçalves; Santos, Talyta Ellen de Jesus dos; Barbosa, Maritza Cavalcante

Background Myelodysplastic syndromes are heterogeneous disorders. Patients with myelodysplastic syndrome disease often have ineffective hematopoiesis, cytopenias, blood cell dysplasia in one or more cell types, and are at high risk for developing acute myeloid leukemia. In myelodysplastic syndrome, mutations of TP53 gene are usually associated with complex karyotype and confer a worse prognosis. In the present ...

Date: 2017   |   Origin: Oasisbr

Clinical events and their relation to the tumor necrosis factor-alpha and inter...

Cavalcante, Jânio Emanuel Andrade; Machado, Rosângela Pinheiro Gonçalves; Laurentino, Marília Rocha; Santos, Talyta Ellen de Jesus dos

Objective/background: Sickle-cell anemia (SCA) is a genetic blood disease characterized by chronic inflammation and a heterogeneous clinical picture. Serum tumor necrosis factor (TNF-alpha) and interleukin 10 (IL-10) levels are associated with the clinical course of SCA. This study aimed to evaluate the association between the frequency of the polymorphisms TNF- alpha-308 G ? A, IL-10-1082 G ? A, IL-10-819 C ? ...

Date: 2016   |   Origin: Oasisbr

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