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White matter alterations in episodic migraine without aura patients assessed wi...

Guadilla, Irene; Fouto, Ana R.; Ruiz-Tagle, Amparo; Esteves, Inês; Caetano, Gina; Silva, Nuno A.; Vilela, Pedro; Gil-Gouveia, Raquel

Objective To assess the efect of modeling free water (FW) on the identifcation of white matter (WM) microstructure alterations using difusion Magnetic Resonance Imaging (dMRI) in episodic migraine without aura patients compared with healthy controls. Background Difusion tensor imaging (DTI) studies examining WM in migraine patients previously overlooked the potential infuence of FW partial volume efects. Correc...


Uncovering longitudinal changes in the brain functional connectome along the mi...

Esteves, Inês; Fouto, Ana R.; Ruiz-Tagle, Amparo; Caetano, Gina; Nunes, Rita G.; Silva, Nuno A. da; Vilela, Pedro; Martins, Isabel Pavão

Changes in large-scale brain networks have been reported in migraine patients, but it remains unclear how these manifest in the various phases of the migraine cycle. Case-control fMRI studies spanning the entire migraine cycle are lacking, precluding a complete assessment of brain functional connectivity in migraine. Such studies are essential for understanding the inherent changes in the brain of migraine pati...


Uncovering longitudinal changes in the brain functional connectome along the mi...

Esteves, Inês; Fouto, Ana R.; Ruiz-Tagle, Amparo; Caetano, Gina; Nunes, Rita G.; da Silva, Nuno A.; Vilela, Pedro; Martins, Isabel Pavão

Background: Changes in large-scale brain networks have been reported in migraine patients, but it remains unclear how these manifest in the various phases of the migraine cycle. Case-control fMRI studies spanning the entire migraine cycle are lacking, precluding a complete assessment of brain functional connectivity in migraine. Such studies are essential for understanding the inherent changes in the brain of m...


Using ECG-derived respiration for explaining BOLD-fMRI fluctuations during rest...

Esteves, Inês; Rodrigues Fouto, Ana Lúcia; Ruiz-Tagle, Amparo; Caetano, Gina; Figueiredo, Patrícia

Recording physiological signals during fMRI is valuable for multiple purposes but often requires additional setup, increasing complexity and participant discomfort. This is particularly challenging in simultaneous EEG-fMRI studies, which typically already include electrocardiogram (ECG) recordings. Here, we aim to leverage the known modulation of ECG by respiration to obtain an ECG-derived respiration (EDR) sig...


Working memory during spontaneous migraine attacks: an fMRI study

Ruiz-Tagle, A.; Figueiredo, Patrícia; Pinto, Joana; Vilela, Pedro; Martins, Isabel Pavão; Gil-Gouveia, Raquel

Objective: To investigate the neural correlates of working memory during a spontaneous migraine attack compared to the interictal phase, using functional magnetic resonance imaging (fMRI). Background: Cognitive disturbances are commonly observed during migraine attacks, particularly in the headache phase. However, the neural basis of these changes remains unknown. Methods: In a fMRI within-subject test-retest d...


Impact of truncating diffusion MRI scans on diffusional kurtosis imaging

Fouto, Ana R.; Henriques, Rafael N.; Golub, Marc; Freitas, Andreia C.; Ruiz-Tagle, Amparo; Esteves, Inês; Gil-Gouveia, Raquel; Silva, Nuno A.

Objective Difusional kurtosis imaging (DKI) extends difusion tensor imaging (DTI), characterizing non-Gaussian difusion efects but requires longer acquisition times. To ensure the robustness of DKI parameters, data acquisition ordering should be optimized allowing for scan interruptions or shortening. Three methodologies were used to examine how reduced difusion MRI scans impact DKI histogram-metrics: 1) the el...


Involvement of the cerebellum in structural connectivity enhancement in episodi...

Matoso, Ana; Fouto, Ana R.; Esteves, Inês; Ruiz-Tagle, Amparo; Caetano, Gina; Silva, Nuno A. da; Vilela, Pedro; Gil-Gouveia, Raquel; Nunes, Rita G.

Background: The pathophysiology of migraine remains poorly understood, yet a growing number of studies have shown structural connectivity disruptions across large-scale brain networks. Although both structural and functional changes have been found in the cerebellum of migraine patients, the cerebellum has barely been assessed in previous structural connectivity studies of migraine. Our objective is to investig...


Medronho: produtos diretos com fileira estabelecida

Botelho, Goreti; Gomes, Filomena; Melo, Filipe; Rodrigues, Ivo; Oliveira, Jorge André; Varejão, Jorge; Franco, Justina; Vidal, Maria Manuel

O medronho é utilizado tradicionalmente para a produção de aguardente, com particular incidência no Algarve, no Alentejo e na Região Centro, nesta última nos distritos de Coimbra, Guarda e Castelo Branco. A Associação de Produtores de Aguardente de Medronho do Barlavento Algarvio (APAGARBE) foi a primeira Associação que se constituiu com os produtores para a venda de aguardente ao público. Sucederam-se outras, ...


Medronho - produtos diretos com fileira estabelecida

Botelho, Goreti; Gomes, Filomena; Melo, Filipe; Rodrigues, Ivo; Oliveira, Jorge André; Varejão, Jorge; Franco, Justina; Vidal, Maria Manuel


Do juveniles who have committed sexual offenses have higher callous-unemotional...

Ramião, Eduarda; Geraldo, Andreia; Figueiredo, Patrícia; Barroso, Ricardo; Barbosa, Fernando

The importance of assessing psychopathic traits in juveniles who have committed sexual offenses has been established in individuals who demonstrate a particularly severe and violent pattern of behavior. Additionally, the assessment of these traits in other juveniles might be relevant considering that higher levels of these traits represent an increased probability of the juvenile committing offenses. This study...


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