Objective To assess the efect of modeling free water (FW) on the identifcation of white matter (WM) microstructure alterations using difusion Magnetic Resonance Imaging (dMRI) in episodic migraine without aura patients compared with healthy controls. Background Difusion tensor imaging (DTI) studies examining WM in migraine patients previously overlooked the potential infuence of FW partial volume efects. Correc...
Changes in large-scale brain networks have been reported in migraine patients, but it remains unclear how these manifest in the various phases of the migraine cycle. Case-control fMRI studies spanning the entire migraine cycle are lacking, precluding a complete assessment of brain functional connectivity in migraine. Such studies are essential for understanding the inherent changes in the brain of migraine pati...
Background: Changes in large-scale brain networks have been reported in migraine patients, but it remains unclear how these manifest in the various phases of the migraine cycle. Case-control fMRI studies spanning the entire migraine cycle are lacking, precluding a complete assessment of brain functional connectivity in migraine. Such studies are essential for understanding the inherent changes in the brain of m...
Recording physiological signals during fMRI is valuable for multiple purposes but often requires additional setup, increasing complexity and participant discomfort. This is particularly challenging in simultaneous EEG-fMRI studies, which typically already include electrocardiogram (ECG) recordings. Here, we aim to leverage the known modulation of ECG by respiration to obtain an ECG-derived respiration (EDR) sig...
Objective: To investigate the neural correlates of working memory during a spontaneous migraine attack compared to the interictal phase, using functional magnetic resonance imaging (fMRI). Background: Cognitive disturbances are commonly observed during migraine attacks, particularly in the headache phase. However, the neural basis of these changes remains unknown. Methods: In a fMRI within-subject test-retest d...
Objective Difusional kurtosis imaging (DKI) extends difusion tensor imaging (DTI), characterizing non-Gaussian difusion efects but requires longer acquisition times. To ensure the robustness of DKI parameters, data acquisition ordering should be optimized allowing for scan interruptions or shortening. Three methodologies were used to examine how reduced difusion MRI scans impact DKI histogram-metrics: 1) the el...
Background: The pathophysiology of migraine remains poorly understood, yet a growing number of studies have shown structural connectivity disruptions across large-scale brain networks. Although both structural and functional changes have been found in the cerebellum of migraine patients, the cerebellum has barely been assessed in previous structural connectivity studies of migraine. Our objective is to investig...
O medronho é utilizado tradicionalmente para a produção de aguardente, com particular incidência no Algarve, no Alentejo e na Região Centro, nesta última nos distritos de Coimbra, Guarda e Castelo Branco. A Associação de Produtores de Aguardente de Medronho do Barlavento Algarvio (APAGARBE) foi a primeira Associação que se constituiu com os produtores para a venda de aguardente ao público. Sucederam-se outras, ...
The importance of assessing psychopathic traits in juveniles who have committed sexual offenses has been established in individuals who demonstrate a particularly severe and violent pattern of behavior. Additionally, the assessment of these traits in other juveniles might be relevant considering that higher levels of these traits represent an increased probability of the juvenile committing offenses. This study...