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How to Unleash the Potential of the Portuguese Registry of Intensive Care Medic...
Mendes, João João; Amaral , Inês; Gonçalves Pereira , João; Paiva, José Artur; Figueiredo, Paulo; Póvoa, Pedro; Guimarães, Teresa; Mergulhão, PauloN/A; N/A
Impact of event scale–revised: A new analysis of its factor structure as applie...
Figueiredo, Paulo; Simões, Inês; Santos, Sónia dos; Valentim, Olga; Sousa, CristinaThis study used the Portuguese version of the Impact of Event Scale-Revised (IES-R) to assess the risk of psychological disturbances associated with the COVID-19 pandemic in two independent samples of the Portuguese population. The psychometric characteristics of the scale were also assessed. Data was collected through an online survey and its internal consistency was examined. The internal consistency of the s...
Impact of event scale–revised: A new analysis of its factor structure as applie...
Figueiredo, Paulo; Simões, Inês; Santos, Sónia dos; Valentim, Olga Sousa; Sousa, Cristina deThis study used the Portuguese version of the Impact of Event Scale-Revised (IES-R) to assess the risk of psychological disturbances associated with the COVID-19 pandemic in two independent samples of the Portuguese population. The psychometric characteristics of the scale were also assessed. Data was collected through an online survey and its internal consistency was examined. The internal consistency of the s...
HER2 Status in RAS and BRAF Wild-Type Metastatic Colorectal Cancer: A Portugues...
Fraga, Teresa; Sousa, Maria João; Magalhães, Joana; Basto, Raquel; Paulo, Judy; Bonito, Nuno; Magalhães, José Paulo; Figueiredo, PauloIntroduction: Colorectal cancer (CRC) is the second-most deadly cancer worldwide. However, there remains a scarcity of precision treatments available for this type of cancer. Amplification or overexpression of human epidermal growth factor receptor 2 (HER2+) is a well-established therapeutic target in gastric and breast cancer. HER2 is positive in approximately 5% of CRC cases and has been implicated in resista...
Public Procurement in Brazil: Evidence of frauds using the Newcomb-Benford Law ...
Sampaio, Adilson; Figueiredo, Paulo; Loiola, ElisabethThis article uses the Newcomb-Benford(NB-Law), or Law of Anomalous Numbers, to analyze the values of Electronic Bidding Processes that occurred in the Purchasing Portal of the Brazilian Federal Government and contained in the newly created website "DadosAbertos.gov.br". In the analysis, all services contracted in the period from 2014 to 2018 were considered. The objective of the research was to analyze the conf...
Diagnosing learning structures and learning capacities in a Public University f...
Loiola, Elisabeth; Assis Neto, Edgar; Figueiredo, Paulo; Soares Junior , Jair SampaioThe objective of this study is to diagnose structures and capabilities of Learning Organizations (LO) in a large, public, Federal Higher Education Institution (HEI) in the Northeast of Brazil, in order to promote them and improve their performance and that of their employees. The quantitative research, of the survey type with a non-random sample, uses the Dimensions of Learning Organization Questionnaire - DLOQ...
A New Look into Cancer-A Review on the Contribution of Vibrational Spectroscopy...
Mamede, Adriana Maria Pires; Santos, Inês P.; Carvalho, Ana L. M. Batista de; Figueiredo, Paulo; Silva, Maria C.; Tavares, Mariana V.; Marques, M. P. M.In 2020, approximately 10 million people died of cancer, rendering this disease the second leading cause of death worldwide. Detecting cancer in its early stages is paramount for patients' prognosis and survival. Hence, the scientific and medical communities are engaged in improving both therapeutic strategies and diagnostic methodologies, beyond prevention. Optical vibrational spectroscopy has been shown to be...
GMP-grade nanoparticle targeted to nucleolin downregulates tumor molecular sign...
Fonseca, Nuno A.; Gregório, Ana C.; Mendes, Vera M.; Lopes, Rui; Abreu, Teresa; Gonçalves, Nélio; Manadas, Bruno; Lacerda, Manuela; Figueiredo, PauloPatients with breast or ovarian cancer have not benefited from improved efficacy with pegylated liposomal doxorubicin relative to free drug, likely due to the limited extent of the enhanced permeability and retention (EPR) effect, further compromising drug bioavailability in the tumor. Herein it is hypothesized that targeting nucleolin overexpressed in tumor endothelial cells (readily accessible from the vascul...
Meeting the needs of breast cancer: a nucleolin’s perspective
Gregório, Ana C.; Lacerda, Manuela; Figueiredo, Paulo; Simões, Sérgio; Dias, Sérgio; Moreira, João NunoA major challenge in the management of breast cancer disease has been the development of metastases. Finding new molecular targets and the design of targeted therapeutic approaches to improve the overall survival and quality of life of these patients is, therefore, of great importance. Nucleolin, which is overexpressed in cancer cells and tumor-associated blood vessels, have been implicated in various processes...
Therapeutic implications of the molecular and immune landscape of triple-negati...
Gregório, Ana C.; Lacerda, Manuela; Figueiredo, Paulo; Simões, Sérgio; Dias, Sérgio; Moreira, João NunoTreatment and management of breast cancer imposes a heavy burden on public health care, and incidence rates continue to increase. Breast cancer is the most common female neoplasia and primary cause of death among women worldwide. The recognition of breast cancer as a complex and heterogeneous disease, comprising different molecular entities, was a landmark in our understanding of this malignancy. Valuing the im...