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A simple protocol for the synthesis of perylene bisimides from perylene tetraca...
Marinho, Elina Margarida Ribeiro; Figueiredo, Pedro Miguel Reis; Araújo, Rui Filipe; Proença, M. Fernanda R. P.Perylene bisimides are highly attractive polycyclic aromatic hydrocarbons due to their photostability associated to unique and characteristic photochemical properties. They have been widely used for analytical purposes, despite the hydrophobicity of most of these compounds. The ring substitution pattern plays an important role in fine-tuning the physicochemical properties that govern solubility and aggregation....
Enzymatic synthesis of amphiphilic polymer-drug conjugates for cancer treatment
Figueiredo, Pedro Miguel ReisTese de Doutoramento em Biologia Experimental e Biomedicina apresentada ao Instituto de Investigação Interdisciplinar; O cancro é a segunda maior causa de morte no mundo. Apesar de esforços intensivos, o número de fármacos ativos contra o cancro é ainda relativamente baixo. Os sistemas de libertação controlada de fármacos baseados em nanopartículas podem ultrapassar as desvantagens intrínsecas dos fármacos admi...
Studies on the synthesis of adenine derivatives and analogues as anticancer dru...
Figueiredo, Pedro Miguel ReisThe adenine and pyrazolopyrimidine nucleus are privileged structures in the design of new bioactive compounds. An extensive and diversified pharmacological activity has been reported in the literature, including cancer treatment. The nature and position of the substituents in the heterocyclic core are crucial for the therapeutic application of these molecules. The objectives of this dissertation included the op...