10 documents found, page 1 of 1
Oral Ang-(1-7) treatment improves white adipose tissue remodeling and hypertens...
Barbosa, Maria Andréa; Sousa, Graziele Galdino de; Castro, Uberdan Guilherme Mendes de; Carneiro, Cláudia Martins; Figueiredo, Vivian PaulinoObjective: Angiotensin (Ang)-(1-7) has preventive effects on metabolic syndrome (MetS). The aim of this study was to evaluate the therapeutic effect of oral Ang-(1-7) on mean arterial pressure (MAP), insulin resistance (IR), inflammatory process, and remodeling of white adipose tissue (WAT) in rats with establishedMetS. Methods: Rats were subjected to control (CT; AIN-93M) or high-fat (HF) diets for 13 wk to in...
Antioxidant effects of oral Ang-(1-7) restore insulin pathway and RAS component...
Figueiredo, Vivian Paulino; Barbosa, Maria Andréa; Castro, Uberdan Guilherme Mendes de; Zacarias, Aline Cruz; Bezerra, Frank SilvaIn prevention studies of metabolic syndrome (MetS), Ang-(1-7) has shown to improve the insulin signaling. We evaluated the HPβCD/Ang-(1-7) treatment on lipid metabolism, renin-angiotensin system (RAS) components, oxidative stress, and insulin pathway in the liver and gastrocnemius muscle and hepatic steatosis in rats with established MetS. After 7 weeks of high-fat (FAT) or control (CT) diets, rats were treated...
The β-blocker carvedilol and the benznidazole modulate the cardiac immune respo...
Horta, Aline Luciano; Figueiredo, Vivian Paulino; Leite, Ana Luísa Junqueira; Costa, Guilherme de Paula; Menezes, Ana Paula de JesusBACKGROUND The infection led by Trypanosoma cruzi persists in mammalian tissues causing an inflammatory imbalance. Carvedilol (Cv), a non-selective beta blocker drug indicated to treat heart failure and antihypertensive has shown to promote antioxidant and immunomodulatory properties which might improve the inflammation induced by T. cruzi. OBJECTIVES Evaluate the role of Cv on the inflammatory response of C57B...
Renovascular hypertension increases serum TNF and CX3CL1 in experimental Trypan...
Silva, M. C.; Azevedo, Maíra Araújo; Figueiredo, Vivian Paulino; Moura Junior, Manoel Ramos de; Coelho Júnior, Diógenes; Martinelli, Patrícia MassaraTrypanosoma cruzi triggers a progressive inflammatory response affecting cardiovascular functions in humans and experimental models. Angiotensin II, a key effector of the renin-angiotensin system, plays roles in mediating hypertension, heart failure, and inflammatory responses. T. cruzi and AngII can induce inflammatory responses by releasing inflammatory mediators. The aim of this study was to evaluate systemi...
CXCL-16, IL-17, and bone morphogenetic protein 2 (BMP-2) are associated with ov...
Ribeiro, Silvana Mara Luz Turbino; Lopes, Laís Roquete; Costa, Guilherme de Paula; Figueiredo, Vivian Paulino; Bajracharya, Deena ShresthaThe current concept of overweight/obesity is most likely related to a combination of increased caloric intake and decreased energy expenditure. Widespread inflammation, associated with both conditions, appears to contribute to the development of some obesity-related comorbidities. Interventions that directly or indirectly target individuals at high risk of developing obesity have been largely proposed because o...
Potential role of Carvedilol in the cardiac immune response induced by experime...
Horta, Aline Luciano; Leite, Ana Luísa Junqueira; Costa, Guilherme de Paula; Figueiredo, Vivian Paulino; Silva, André Talvani Pedrosa daTrypanosoma cruzi causes a cardiac infection characterized by an inflammatory imbalance that could become the inciting factor of the illness. To this end, we evaluated the role of carvedilol, a beta-blocker with potential immunomodulatory properties, on the immune response in C57BL/6 mice infected with VL-10 strain of T. cruzi in the acute phase. Animals ( = 40) were grouped: (i) not infected, (ii) infected, (i...
Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL...
Bandeira, Ana Carla Balthar; Silva, Rafaella Cecília da; Rossoni Júnior, Joamyr Victor; Figueiredo, Vivian Paulino; Silva, André Talvani Pedrosa daAcetaminophen (APAP) is an antipyretic and analgesic drug that, in high doses, leads to severe liver injury and potentially death. Oxidative stress is an important event in APAP overdose. Researchers are looking for natural antioxidants with the potential to mitigate the harmful effects of reactive oxygen species in different models. Lycopene has been widely studied for its antioxidant properties. The aim of th...
Avaliação de parâmetros inflamatórios na infecção aguda e crônica de camundongo...
Figueiredo, Vivian PaulinoPrograma de Pós-Graduação em Ciências Biológicas. Núcleo de Pesquisas em Ciências Biológicas, Pró-Reitoria de Pesquisa de Pós Graduação, Universidade Federal de Ouro Preto.; O estado nutricional vem se destacando nas interações entre agentes infecciosos e a resposta imunofisiológica de seus hospedeiros apresentando-se diretamente ligado à qualidade da dieta na qual o indivíduo é submetido. Como exemplo, uma die...
Trypanosoma cruzi antigens induce inflammatory angiogenesis in a mouse subcutan...
Silva, Francisca Hildemagna Guedes da; Bajracharya, Deena Shrestha; Salles, Beatriz Cristina Silveira; Figueiredo, Vivian Paulino; Lopes, Laís RoqueteAcute inflammation and angiogenesis are persistent features of several pathological conditions induced by biological agents leading to the resolution of local and systemic events. Glycoproteins derived from the protozoan Trypanosoma cruzi are suggested to mediate angiogenesis induced by inflammatory cells with still undescribed mechanisms. In this study, we investigated the effects of total antigen from trypoma...
Benznidazole microcrystal preparation by solvent change precipitation and in vi...
Maximiano, Flávia Pires; Paula, Lívia Maria de; Figueiredo, Vivian Paulino; Andrade, Isabel Mayer de; Silva, André Talvani Pedrosa daBenznidazole (BNZ) is traditionally used to treat Chagas disease. Despite its common use, BNZ has a poor water solubility and a variable bioavailability. The purpose of this study was to prepare BNZ microcrystals by solvent change precipitation and to study the effects of BNZ micronisation on therapeutic efficiency using a murine model of Chagas disease. The solvent change precipitation procedure was optimised ...