4 documents found, page 1 of 1
Recent insights into mitochondrial targeting strategies in liver transplantation
Martins, Rui Miguel; Teodoro, João Soeiro; Furtado, Emanuel; Rolo, Anabela Pinto; Palmeira, Carlos Marques; Tralhão, José GuilhermeIschemia/reperfusion (I/R) injury in liver transplantation can disrupt the normal activity of mitochondria in the hepatic parenchyma. This potential dysfunction of mitochondria after I/R injury could be responsible for the initial poor graft function or primary nonfunction observed after liver transplantation. Thus, determining the mechanisms that lead to human hepatic mitochondrial dysfunction might contribute...
Addition of Berberine to Preservation Solution in an Animal Model of Ex Vivo Li...
Martins, Rui Miguel; Rolo, Anabela Pinto; Teodoro, João Soeiro; Furtado, Emanuel; Oliveira, Rui Caetano; Tralhão, José GuilhermeLiver transplantation is a therapeutic regimen to treat patients with non-malignant end-stage liver diseases and malignant tumors of hepatic origin. The ischemia/reperfusion (I/R) injury in liver transplantation is associated with disruption of mitochondrial function in the hepatic parenchyma. Several studies have been conducted in animal models to identify pharmacological therapeutic strategies to minimize the...
Lack of Additive Effects of Resveratrol and Energy Restriction in the Treatment...
Milton-Laskibar, Iñaki; Aguirre, Leixuri; Fernández-Quintela, Alfredo; Rolo, Anabela P.; Teodoro, João Soeiro; Palmeira, Carlos M.; Portillo, María PThe aims of the present study were to analyze the effect of resveratrol on liver steatosis in obese rats, to compare the effects induced by resveratrol and energy restriction and to research potential additive effects. Rats were initially fed a high-fat high-sucrose diet for six weeks and then allocated in four experimental groups fed a standard diet: a control group, a resveratrol-treated group, an energy rest...
Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: A pos...
Teodoro, João Soeiro; Duarte, Filipe Valente; Gomes, Ana Patrícia; Varela, Ana Teresa; Peixoto, Francisco Manuel; Rolo, Anabela Pinto; Palmeira, C. M.Berberine is an isoquinoline alkaloid with anti-diabetic properties. Despite the central role of liver and thus hepaticmitochondria inwhole-bodymetabolism, berberine effects on hepaticmitochondrial function in an obesity model are still unknown. Here, we demonstrate that berberine treatment recovers mitochondrial efficiency when altered by a high-fat feeding.Mitochondria isolated from the liver of high-fat fed ...