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Immune-microbe crosstalk : modulation of adaptive immune system by the microbio...
Figueiredo-Campos, PatriciaAdaptive immune responses are supported by lymphocytes that are broadly divided into B and T cells, which provide antibody and cell-mediated immune responses, respectively. Adaptive immunity is characterized by a specific pathogen recognition, generation of memory, and regulation of homeostasis. Lymphocytes develop and are activated in the lymphoid organs and can also re-circulate within the tissues. Intestinal...
Intestinal tissue-resident T cell activation depends on metabolite availability
Konjar, Spela; Ferreira, Cristina; Carvalho, Filipa; Figueiredo-Campos, Patricia; Fanczal, Júlia; Ribeiro, Sofia; Morais, Vanessa A.; Veldhoen, MarcThe metabolic capacity of many cells is tightly regulated and can adapt to changes in metabolic resources according to environmental changes. Tissue-resident memory (TRM) CD8+ T cells are one of the most abundant T cell populations and offer rapid protection against invading pathogens, especially at the epithelia. TRM cells metabolically adapt to their tissue niche, such as the intestinal epithelial barrier. In...
Humoral immune response of SARS-CoV-2-infected patients with cancer: influencin...
Esperança Martins, Miguel; Gonçalves, Lisa; Soares De Pinho, Inês; Gomes, Andreia; Montesinos Serrano, Marta; Blankenhaus, BirteBackground: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients with cancer show worse outcomes compared with patients without cancer. The humoral immune response (HIR) of patients with cancer against SARS-CoV-2 is not well characterized. To better understand it, we conducted a serological study of hospitalized patients with cancer infected with SARS-CoV-2. Materials and methods: This...
Seroprevalence of anti‐SARS‐CoV‐2 antibodies in COVID‐19 patients and healthy v...
Figueiredo-Campos, Patricia; Blankenhaus, Birte; Mota, Catarina; Gomes, Andreia; Serrano, Marta; Ariotti, Silvia; Costa, Catarina; Nunes-Cabaço, HelenaSARS-CoV-2 has emerged as a human pathogen, causing clinical signs, from fever to pneumonia-COVID-19-but may remain mild or asymptomatic. To understand the continuing spread of the virus, to detect those who are and were infected, and to follow the immune response longitudinally, reliable and robust assays for SARS-CoV-2 detection and immunological monitoring are needed. We quantified IgM, IgG, and IgA antibodi...
Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells
Ferreira, Cristina; Barros, Leandro; Baptista, Marta; Blankenhaus, Birte; Barros, André; Figueiredo-Campos, Patricia; Konjar, Spela; Lainé, AlexandraTissue-resident memory T (TRM) cells, functionally distinct from circulating memory T cells, have a critical role in protective immunity in tissues, are more efficacious when elicited after vaccination and yield more effective antitumor immunity, yet the signals that direct development of TRM cells are incompletely understood. Here we show that type 1 regulatory T (Treg) cells, which express the transcription f...
Eimeria vermiformis Infection model of Murine small intestine
Figueiredo-Campos, Patricia; Ferreira, Cristina; Blankenhaus, Birte; Veldhoen, MarcEimeria vermiformis is a tissue specific, intracellular protozoan that infects the murine small intestinal epithelia, which has been widely used as a coccidian model to study mucosal immunology. This mouse infection model is valuable to investigate the mechanisms of host protection against primary and secondary infection in the small intestine. Here, we describe the generation of an E. vermiformis stock solutio...