2 documents found, page 1 of 1
Effects of non-conventional sterilisation methods on PBO-reinforced PVA hydroge...
Pires, Tomás; Oliveira, Andreia Sofia; Marques, Ana Clara; Salema-Oom, Madalena; Figueiredo-Pina, Célio G.; Silva, Diana; Serro, Ana PaulaArticular cartilage (AC) degradation is a recurrent pathology that affects millions of people worldwide. Polyvinyl alcohol (PVA) hydrogels have been widely explored for AC replacement. However, their mechanical performance is generally inadequate, and these materials need to be reinforced. Moreover, to be used in a clinical setting, such materials must undergo effective sterilisation. In this work, a PVA hydrog...
PVA-based hydrogels loaded with diclofenac for cartilage replacement
Branco, Ana C.; Oliveira, Andreia S.; Monteiro, Inês; Nolasco, Pedro; Silva, Diana C.; Figueiredo-Pina, Célio G.; Colaço, Rogério; Serro, Ana P.Polyvinyl alcohol (PVA) hydrogels have been widely studied for cartilage replacement due to their biocompatibility, chemical stability, and ability to be modified such that they approximate natural tissue behavior. Additionally, they may also be used with advantages as local drug delivery systems. However, their properties are not yet the most adequate for such applications. This work aimed to develop new PVA-b...