2 documents found, page 1 of 1
Searching for drug leads targeted to the hydrophobic cleft of dengue virus caps...
Ortlieb, Liliane O.; Caruso, Ícaro P. [UNESP]; Mebus-Antunes, Nathane C.; Da Poian, Andrea T.; Petronilho, Elaine da C.; Figueroa-Villar, José DanielMade available in DSpace on 2022-04-29T08:37:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01; We synthesised and screened 18 aromatic derivatives of guanylhydrazones and oximes aromatic for their capacity to bind to dengue virus capsid protein (DENVC). The intended therapeutic target was the hydrophobic cleft of DENVC, which is a region responsible for its anchoring in lipid droplets in the infe...
Nuclear Magnetic Resonance (NMR), Infrared (IR) and Mass Spectrometry (MS) stud...
Pereira, Wagner Luiz; Pires, Diego Arantes Teixeira; Teixeira, Róbson Ricardo; Figueroa-Villar, José Daniel; Nascimento, Claudia Jorge doThe keto-enol tautomerism of 3-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohexen-1-yl)isobenzofuran- 1(3H-one (1), 3-(2-hydroxy-6-oxocyclohex-1-enyl)isobenzofuran-1(3H)-one (2), 3-(2- hydroxy- 4-methyl-6-oxocyclohex-1-enyl)isobenzofuran-1(3H)-one (3), 3-(2-hydroxy-5-oxocyclopent-1-enyl) isobenzofuran-1(3H)-one (4) and 2-(3-oxo-1,3-dihydroisobenzofuran-1-yl)-1H-indene-1,3(2H)-dione (5) were investigated. We noticed that ...