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Modulation of the ubiquitin-proteasome system by circulating (poly)phenol-deriv...
Ferreira, Sofia; Menezes, Regina; Trougakos, Ioannis P.; Gumeni, Sentiljana; Bolanos-Garcia, Victor M.; Nunes dos Santos, ClaudiaFunding Information: This article/publication is based upon work from COST Action ProteoCure, CA20113, supported by COST (European Cooperation in Science and Technology). This research was funded by national funds through FCT\u2014Foundation for Science and Technology, I.P. (Portugal), under the [DOI 10.54499/UIDB/04567/2020] and [DOI 10.54499/UIDP/04567/2020] projects. SF is funded by FCT (UI/BD/151421/2021) a...
The (Poly)phenol-Carbohydrate Combination for Diabetes
de Matos, Ana Marta; Menezes, ReginaFunding: Centro de Química Estrutural is a Research Unit funded by Fundação para a Ciência e Tecnologia through projects UIDB/00100/2020 and UIDP/00100/2020. Institute of Molecular Sciences is an Associate Laboratory funded by FCT through project LA/P/0056/2020. A.M. Matos thanks FCT, CQE, and Faculdade de Ciências da Universidade de Lisboa for her CEECInst Junior Researcher Contract, and FCT for funding throug...
Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocyto...
Rosado-Ramos, Rita; Poças, Gonçalo M.; Marques, Daniela; Foito, Alexandre; M Sevillano, David; Lopes-da-Silva, Mafalda; Gonçalves, Luís G.Parkinson's Disease (PD) is a common neurodegenerative disorder affecting millions of people worldwide for which there are only symptomatic therapies. Small molecules able to target key pathological processes in PD have emerged as interesting options for modifying disease progression. We have previously shown that a (poly)phenol-enriched fraction (PEF) of Corema album L. leaf extract modulates central events in...
Urolithin B
Raimundo, Ana F.; Ferreira, Sofia; Pobre, Vânia; Lopes-da-Silva, Mafalda; Brito, José A.; dos Santos, Daniel J.V.A.; Saraiva, NunoFunding Information: This study was supported by FCT–Fundação para a Ciência e a Tecnologia (grants UIDB/04567/2020 and UIDP/ 04567/2020 to CBIOS, PTDC/BIA-MOL/31104/2017, and PhD grants PD/BD/135504/2018 to AFR and UI/BD/151421/2021 to SF. RM is funded by FCT Scientific Employment Stimulus contract with the reference number CEEC/04567/ CBIOS/2020. Authors also acknowledge COFAC/ILIND – Cooperativa De Formação ...
Polyphenols and Their Metabolites in Renal Diseases
Guerreiro, Íris; Ferreira-Pêgo, Cíntia; Carregosa, Diogo; Santos, Cláudia N.; Menezes, Regina; Fernandes, Ana S.; Costa, João G.Funding Information: Funding: This work was supported by FCT–Fundação para a Ciência e a Tecnologia (grants UIDB/04567/2020 and UIDP/04567/2020 to CBIOS, PTDC/BIA-MOL/31104/2017, and PhD grants 2020.07813.BD to Í.G. and 2020.04630.BD to D.C.). C.F.-P. and R.M. are funded by FCT Scientific Employment Stimulus contract with the reference numbers CEEC/CBIOS/NUT/2018 and CEEC/04567/CBIOS/2020, respectively. Authors...
Updated Information of the Effects of (Poly)phenols against Type-2 Diabetes Mel...
Menezes, Regina; Matafome, Paulo; Freitas, Marisa; García-Conesa, María TeresaFunding: This study was supported by the Fundação para a Ciência e Tecnologia (FCT)/Ministério da Ciência e do Ensino Superior; grant numbers PTDC/BIA-MOL/31104/2017 (RM), UID/QUI/50006/2020 (MF), UIDB/04567/2020 and UIDP/04567/2020 (CBIOS); UIDB/04539/2020 and UIDBP/4539/2020 (CIBB). COMPETE-FEDER funds (POCI-01-0145-FEDER-007440 and POCI-01-0145-FEDER-031712). The authors would like to acknowledge the support...
Rice Compounds with Impact on Diabetes Control
Pereira, Cristiana; Lourenço, Vanda M.; Menezes, Regina; Brites, Carla2020.09555BD UIDB/04551/2020 CEEC/04567/CBIOS/2020 PTDC/BIA-MOL/31104/2017 UIDB/04567/2020 UIDP/04567/2020; Rice is one of the most cultivated and consumed cereals worldwide. It is composed of starch, which is an important source of diet energy, hypoallergenic proteins, and other bioactive compounds with known nutritional functionalities. Noteworthy is that the rice bran (outer layer of rice grains), a side-str...
Small molecule fisetin modulates alpha-Synuclein aggregation
Rosado-Ramos, Rita; Godinho-Pereira, Joana; Marques, Daniela; Figueira, Inês; Outeiro, Tiago Fleming; Menezes, Regina; Dos Santos, Cláudia NunesFunding Information: iNOVA4Health Research Unit (LISBOA-01-0145-FEDER-007344), which is co-funded by Funda??o para a Ci?ncia e Tecnologia (FCT)/Minist?rio da Ci?ncia e do Ensino Superior, through national funds, and by FEDER under the PT2020 Partnership Agreement, is acknowledged. Authors would like to acknowledge FCT for financial support of RR (SFRH/BD/116597/2016). JP, RR, GG, and CNS acknowledges funding vi...
Urolithins
Raimundo, Ana F.; Ferreira, Sofia; Tomás-Barberán, Francisco A.; Santos, Claudia N.; Menezes, ReginaFunding Information: Funding: This study was funded by Fundação para a Ciência e Tecnologia (FCT)/Ministério da Ciência e do Ensino Superior, grant numbers PTDC/BIA-MOL/31104/2017 (RM) and UIDB/04567/2020 and UIDP/ 04567/2020 (CBIOS). iNOVA4Health Research Unit (LISBOA—01–0145—FEDER—007344), which is cofunded by FCT/Ministério da Ciência e do Ensino Superior, through national funds, and by FEDER under the PT202...
Supercritical CO2 Extraction as a Tool to Isolate Anti-Inflammatory Sesquiterpe...
Baixinho, João P.; Anastácio, José D.; Ivasiv, Viktoriya; Cankar, Katarina; Bosch, Dirk; Menezes, Regina; de Roode, Matthew; Santos, Cláudia Nunes DosFunding: This work was conducted under the “CHIC” project (H2020-NMBP-BIO-2017) with financial support received from the EU Horizon 2020 research and innovation programme under grant agreement N. 760891.; Cichorium intybus L. or chicory plants are a natural source of health-promoting compounds in the form of supplements such as inulin, as well as other bioactive compounds such as sesquiterpene lactones (SLs). A...