3 documents found, page 1 of 1
Patient-derived explants of colorectal cancer: histopathological and molecular ...
da Mata, Sara; Franchi-Mendes, Teresa; Abreu, Sofia; Filipe, Bruno; Morgado, Sónia; Mesquita, Marta; Albuquerque, Cristina; Fonseca, RicardoColorectal cancer (CRC) is one of the most common cancers worldwide. Although short-term cultures of tumour sections and xenotransplants have been used to determine drug efficacy, the results frequently fail to confer clinically useful information. Biomarker discovery has changed the paradigm for advanced CRC, though the presence of a biomarker does not necessarily translate into therapeutic success. To improve...
Familial colorectal cancer type X: clinical, pathological and molecular charact...
Ferreira, Sara; Lage, Pedro; Sousa, Rita; Claro, Isabel; Francisco, Inês; Filipe, Bruno; Suspiro, Alexandra; Chaves, Paula; Rodrigues, PaulaSome families fulfilling the Amsterdam Criteria (AC) differ from the Lynch syndrome (LS) in that colorectal cancers (CRC) do not present microsatellite instability (MSI) and DNA mismatch repair gene mutations are not found. These families have been designated as Familial Colorectal Cancer type X (XS) and their genetic basis remains unknown.In families fulfilling AC for LS: 1) To perform MSI testing in CRC and t...
Need of new clinical criteria for the identification of genetic Lynch syndrome.
Sousa, Rita; Lage, Pedro; Ferreira, Sara; Claro, Isabel; Francisco, Inês; Filipe, Bruno; Albuquerque, Cristina; Suspiro, Alexandra; Rodrigues, PaulaSurveillance programs in families with Hereditary Non-Polyposis Colorectal Cancer (HNPCC), which is an autossomal dominant disease, decrease colorectal carcinoma mortality. There are multiple clinical criteria for the identification of these families, mainly: the Amsterdam Criteria (ACI), the modified Amsterdam Criteria (ACII) and the Bethesda Guidelines (BG).To correlate, in families with HNPCC, the clinical c...