Background & objectives: Tumour-infiltrating lymphocytes (TILs) may have an impact on prognosis in non-small cell lung cancer (NSCLC) and may affect the efficacy of treatment. We aim to characterize TILs in advanced NSCLC with PD-L1 score>50%, treated with first-line immune checkpoint inhibitors. Methods: We performed a single-centre retrospective study. Patients diagnosed with advanced NSCLC with PD-L1>50%, fr...
The small world of matter is getting smaller and smaller. Nano sciences in recent years had huge developments allowing nanotechnologies to take enormous steps in the development of materials and processes. Numerous applications in a wide scope of fields are very beneficial for humans, and much research in development is very promising. Applications in medicine, industry, electronics, energy, or aeronautics are ...
The small world of matter is getting smaller and smaller. Nano sciences in recent years had huge developments allowing nanotechnologies to take enormous steps in the development of materials and processes. Numerous applications in a wide scope of fields are very beneficial for humans, and much research in development is very promising. Applications in medicine, industry, electronics, energy, or aeronautics are ...
Made available in DSpace on 2022-04-28T17:22:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-01-01; Scope management is an area of project management defined by PMBoK, which has processes to register and control everything that belongs to the project boundaries. Although the relevance of this area to the success of projects, its application is still a challenge, which is potentialized by the lack of c...
Made available in DSpace on 2022-04-28T17:30:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-01-01; Requirements Engineering has suffered difficulties caused by communication failures between business and Information Technology teams (IT). The knowledge of the enterprise's business domain is very important for the systems analysts when developing software solutions to automate activities and processes...
This study examines the impact of the quality of board members’ educational background on the financial performance of a group of Eurozone banks. Return on average assets (ROAA), Return on average equity (ROAE), and Tobin’s Q are used as measures to assess bank financial performance. Three indices are used as proxies for board members’ educational qualifications: Eduindex, for all academic qualifications in are...
We used the random walk to model the problem of reserves. The classic case of a stochastic process is the example of random walks, which are used to study a set of phenomena and, particularly, as in this article, models of reserves evolution. Random walks also allow the construction of significant complex systems and are also used as an instrument of analysis, being used in the sense of giving a theoretical cha...
Potential innovators need to overcome many challenges. One such challenge is confirmation bias in decision-making. Human evolution has programmed the brain to act quickly in the face of a threat in the environment. In this way, thinking and (instantaneously) acting rationally is almost impossible for most people. This causes several negative effects on decision-making, notably cognitive biases. For example, an ...
Made available in DSpace on 2021-06-26T02:54:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Associative classifiers (ACs) are predictive models built based on association rules (ARs). Model construction occurs in steps, one of them aimed at sorting and pruning a set of rules. Regarding ordering, usually objective measures (OMs) are...
In the last decade, the United Nations took important steps for the creation of a new instrument for biodiversity protection in areas beyond national jurisdiction. This put under discussion the central issues of international commons management and of the governance model for the High Seas. The aim of this paper is to discuss and evaluate critically the political negotiations already made and yet to come, as we...