106 documents found, page 1 of 11

Kaposi’s Sarcoma: Demographic and Clinical Features, Histopathology, Treatment,...

Introduction: Kaposi’s sarcoma (KS) is a rare angioproliferative neoplasm associated with human herpesvirus 8 infection, presenting as four subtypes: classic, endemic, iatrogenic, and epidemic. While well documented globally, comprehensive data on KS in Portugal remain scarce. The aim of this retrospective study was to provide a detailed analysis of KS cases diagnosed at Hospital Santa Maria, in Lisbon, between...

Parvovirus B19 in Adolescents and Adults: A Case Series of Clinical Mimicry

Parvovirus B19 (PvB19), the etiological agent of erythema infectiosum, can manifest in diverse clinical forms. This study underscores the virus’s capacity to mimic other diseases, as illustrated by the diagnostic challenges encountered across five cases. The first three cases correspond to an overlap of papulo-purpuric gloves and socks syndrome with petechial exanthema with periflexural and periorificial distri...

Successful treatment of extragenital lichen sclerosus with narrow-band UVB phot...

Lichen sclerosus (LS) is a chronic inflammatory skin condition characterized by progressive epidermal atrophy and hypopigmentation, usually affecting the anogenital area. Patients may also present with extragenital lesions,though only 6% of LS cases are isolated to extragenital skin. Extragenital lichen sclerosus (EGLS) can be localized or widespread. Given the rare nature of extragenital-only forms of LS, ther...

Update on Generalized Pustular Psoriasis.

Generalized pustular psoriasis (GPP) is a rare but severe inflammatory skin disease characterized by the eruption of widespread sterile pustules, often accompanied by systemic inflammation. Although GPP can coexist with plaque psoriasis, it is increasingly recognized as a distinct entity with unique clinicopathological, immunologic, and genetic features. The dysregulated IL-36 pathway, including mutations in th...

Viral genetics and transmission dynamics in the second wave of mpox outbreak in...

Tumor-infiltrating T cells in skin basal cell carcinomas and squamous cell carc...

Basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) are high-incidence, non-melanoma skin cancers (NMSCs). The success of immune-targeted therapies in advanced NMSCs led us to anticipate that NMSCs harbored significant populations of tumor-infiltrating lymphocytes with potential anti-tumor activity. The main aim of this study was to characterize T cells infiltrating NMSCs. Flow cytometry and immuno...

Unusual cutaneous adverse reaction to an erectile dysfunction drug: a case report

We presents an unique and significant case of Acute Generalized Exanthematous Pustulosis (AGEP) associated with the use of tadalafil, a phosphodiesterase type 5 inhibitor for erectile dysfunction. AGEP, typically linked to antibiotics and antiepileptics, had not been previously reported with tadaladil in the MEDLINE database. The case involved a 40-year-old male who developed an erythematous rash, fever and ste...

Epidemiology of Psoriasis in Portugal: A Population-Based Study

Introduction: Psoriasis is a common, chronic, and inflammatory skin disorder with a high personal, social and economic burden and important implications for healthcare systems. The aim of this study was to provide an epidemiological characterization of individuals with psoriasis in Portugal.Material and Methods: A large observational, cross-sectional, nationwide, population-based survey study developed by the P...

Portuguese Consensus on Acute Porphyrias: Diagnosis, Treatment, Monitoring and ...

Acute porphyrias are a group of rare genetic metabolic disorders, caused by a defect in one of the enzymes involved in the heme biosynthesis, which results in an abnormally high accumulation of toxic intermediates. Acute porphyrias are characterized by potentially life-threatening attacks and, for some patients, by chronic manifestations that negatively impact daily functioning and quality of life. Clinical man...

Exuberant Plexiform Neurofibroma

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