15 documents found, page 1 of 2
Differentiating Factors of Clinical Trial Sites in Portugal
Oliveiros, Bárbara; Pimentel, Francisco; Brandão, Inês; Silva, SóniaClinical research is developing exponentially in Portugal. It provides patients with early access to innovative molecules, helping to improve healthcare provision, the life expectancy and quality of life of the Portuguese population. However, the number of clinical trials carried out in Portugal is significantly lower than in other countries of a similar size, and the full potential of the country has not yet b...
Polypharmacy and drug interactions in older patients with cancer receiving chem...
Ferraz Oliveira, Rita; Oliveira, Ana Isabel; Cruz, Agostinho; Ribeiro, Oscar; Afreixo, Vera; Pimentel, FranciscoPolypharmacy in older adults with cancer receiving chemotherapy leads to increased risks of drug interactions, translating in potential hazardous health outcomes. This study aims to assess the prevalence of polypharmacy, drug–drug interactions (DDIs), and severe-drug interactions (SDIs) in older patients with cancer. Antineoplastic agents (ANAs) involvement and possible risk contexts (comorbidities with cardiac...
Quality of Life and Mindfulness in Oncology: Randomized controlled study in Por...
Lopes, Carlos; Shannon, David; Almeida, Luís; Pimentel, FranciscoObjectives: To assess the acceptability, and measure the impact on the health-related quality of life (QoL), of a mindfulness-based intervention (MBI) in supportive care of Portuguese cancer survivors. Methods: In 26 cancer outpatients, mostly women (96%), mostly with breast (58%) and gastrointestinal (23%) cancers, randomly assigned to intervention and control groups, we have measured QoL and Mindfulness at ra...
Managing severe dysgeusia and dysosmia in lung cancer patients: a systematic sc...
Spencer, Ana Sofia; Dias, David da Silva; Capelas, Manuel Luís; Pimentel, Francisco; Santos, Teresa; Neves, Pedro Miguel; Mäkitie, Antti; Ravasco, PaulaIntroduction: Lung cancer (LC) is highly prevalent worldwide, with elevated mortality. In this population, taste and smell alterations (TSAs) are frequent but overlooked symptoms. The absence of effective therapeutic strategies and evidence-based guidelines constrain TSAs’ early recognition, prevention and treatment (Tx), promoting cancer-related malnutrition and jeopardizing survival outcomes and quality of li...
Qualidade de vida em doentes com melanoma cutâneo maligno das extremidades subm...
Baeta, Cristina; Narciso, Jorge; Amaral, Rita; Ribeiro, Matilde; Araújo, António; Pimentel, FranciscoMelanoma cutâneo maligno (MM) pode ser considerado uma doença crónica, porque a incidência está a aumentar e a mortalidade a diminuir. A Perfusão Isolada dos Membros (PIM) é uma técnica/terapêutica invasiva que permite aos doentes com MM disseminado/volumoso/irressecável nas extremidades evitarem amputação e regredirem estádio da doença. O interesse da comunidade clínica/científica na Qualidade de Vida (QdV) em...
Health-related quality of life and physical fitness in breast cancer patients: ...
Antunes, Pedro; Esteves, Dulce; Nunes, Célia; Joaquim, Ana; Pimentel, Francisco; Moutinho, José FonsecaAfter breast cancer diagnosis (BCD), localized breast cancer (BC) patients are treated with curative intent by several therapeutic modalities. Despite the benefit of those therapies, the induction of side effects is acommon consequence affecting psychosocial and physiological outcomes. This quasi-experimental study compared physical fitness in recent-term (14–30 months; n= 11) and later-term (74–92 months; n= 8...
Cancer Palliative Care: Technology Support for Quality of Life Assessment of Fa...
Silveira, Augusta Pureza; Amaral, Sara; Castro, Ana Rosa; Monteiro, Eurico; Pimentel, Francisco; Sequeira, TeresaFamily caregivers (FCs) are fundamental for quality of life (QoL) optimization and well-being of cancer patients, contributing to the quality of palliative care services. The present study aimed to evaluate the QoL of FCs caring for oncological patients admitted to the Palliative Care Service of the Portuguese Oncology Institute of Porto. It was also intended to identify multidimensional problems that could gui...
Polypharmacy in older patients with cancer
Ferraz Oliveira, Rita; Afreixo, Vera; Santos, João; Mota, Priscilla; Cruz, Agostinho; Pimentel, FranciscoPolypharmacy is associated with drug–drug interactions, adverse drug events, hospitalization, increased mortality and rising costs. Older cancer patients are potentially vulnerable to polypharmacy because cancer treatment often involves exposure to chemotherapy and other adjunctive or supportive medication.
Translation and adaptation of the Spirituality and Spiritual Care Rating Scale ...
Martins, Andreia Raquel; Pinto, Sara; Caldeira, Sílvia; Pimentel, FranciscoTheoretical framework: The knowledge on spirituality in Nursing has increased in Portugal, but there is still low evidence on the nurses’ perception of this dimension of care, as well as limited instruments in portuguese which allow measuring related phenomena. The Spirituality and Spiritual Care Rating Scale (SSCRS) allows assessing the nurses’ perception of spirituality and spiritual care. Objectives: To tran...
Sulforaphane induces oxidative stress and death by p53-independent mechanism: i...
Oliveira, José Miguel P. Ferreira de; Costa, Maria; Pedrosa, Tiago; Pinto, Pedro; Remédios, Catarina; Oliveira, Helena; Pimentel, FranciscoSulforaphane (SFN) is a naturally-occurring isothiocyanate best known for its role as an indirect antioxidant. Notwithstanding, in different cancer cell lines, SFN may promote the accumulation of reactive oxygen species (ROS) and cause cell death e.g. by apoptosis. Osteosarcoma often becomes chemoresistant, and new molecular targets to prevent drug resistance are needed. Here, we aimed to determine the effect o...