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BK virus salivary shedding and viremia in renal transplant recipients
Sarmento,Dmitry José de Santana; Palmieri,Michelle; Galvão,Gustavo Souza; Tozetto-Mendoza,Tânia Regina; Canto,Cynthia Motta do; Pierrotti,Ligia CameraAbstract Objectives: This study aimed to verify the presence of polyomavirus BK (BKPyV) in the saliva of kidney transplant recipients and to correlate it with blood viremia. Material and Methods: We have conducted a cross-sectional study with a sample involving 126 renal transplant recipients. 126 samples of saliva and 52 samples of blood were collected from these patients. Detection and quantification of BKPyV...
Natalizumab treatment for multiple sclerosis: updates and considerations for sa...
Nali,Luiz Henrique da Silva; Moraes,Lenira; Fink,Maria Cristina Domingues; Callegaro,Dagoberto; Romano,Camila Malta; Oliveira,Augusto Cesar Penalva deNatalizumab is currently one of the best options for treatment of patients with Multiple Sclerosis who have failed traditional prior therapies. However, prolonged use, prior immunosuppressive therapy and anti-JCV antibody status have been associated with increased risk of developing progressive multifocal leukoencephalopathy (PML). The evaluation of these conditions has been used to estimate risks of PML in the...