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Machado-Joseph disease in a Nigerian family: mutational origin and review of th...

Ogun, SA; Martins, S; Adebayo, PB; Dawodu, CO; Sequeiros, J; Finkel, MF

Machado-Joseph disease (MJD) has been described in Africans, but no cases have been reported from Nigeria. Current MJD global distribution results from both the ancestral populations-of-origin and the founder effects of mutations, some as a consequence of the Portuguese sea travels in the 15th to 16th century. Two main ancestral haplotypes have been identified: the Machado lineage, which is more recent, predomi...

Date: 2015   |   Origin: Repositório Aberto da Universidade do Porto
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