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Prospective Study of Loss of Health-Related Quality Adjusted Life Years in Chil...

Rodrigues, F; Marlow, R; Gouveia, C; Correia, P; Brett, A; Silva, C; Gameiro, I; Rua, I; Dias, J; Martins, M; Diogo, R; Lopes, T; Hipólito, E

Introduction and aims: Although usually benign, varicella can lead to serious complications and sometimes long-term sequelae. Vaccines are safe and effective but not yet included in immunisation programmes in many countries. We aimed to quantify the impact on health-related quality of life (HRQoL) in terms of quality-adjusted life years (QALY) in children with varicella and their families, key to assessing cost...


Safety and Efficacy of Oral Fexofenadine in Children with Seasonal Allergic Rhi...

Meltzer, E; Scheinmann, P; Rosado-Pinto, J; Bachert, C; Hedlin, G; Wahn, U; Finn, A; Ruuth, E

Allergic rhinitis is one of the most common clinical conditions in children; however, data regarding the safety of antihistamines in children with seasonal allergic rhinitis are limiting. To evaluate the safety and efficacy of fexofenadine in children with seasonal allergic rhinitis, data were pooled from three, double-blind, randomized, placebo-controlled, parallel-group, 2-week trials in children (6-11 year) ...


Fexofenadine is Efficacious and Safe in Children (Aged 6-11 Years) with Seasona...

Rosado-Pinto, J; Wahn, U; Meltzer, E; Finn, A; Kowalski, M; Decosta, P; Hedlin, G; Scheinmann, P; Bachert, C; Baena-Cagnani, C; Potter, P; Simons, F

Background: This is the first prospective, randomized, doubleblind, placebo-controlled study showing statistical improvement of an H1-antihistamine in children with seasonal allergic rhinitis in all symptoms throughout the entire treatment period. Objective: This randomized, placebo-controlled, parallelgroup,double-blind study was performed to assess the efficacy and safety of fexofenadine in children with seas...


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