5 documents found, page 1 of 1
HLA-DR expression in cytotoxic T lymphocytes
Salvador, Rute; Correia, Bruna Filipa; Grosa, Daniela; Martins, Telma; Soares Baal, Suelen Cristina; Saraiva, Diana Pereira; Cristóvão-Ferreira, SofiaT cell-based therapies, involving ex vivo expansion of patients’ T lymphocytes, hold significant promise for chemotherapy resistant cases of breast cancer (BC), although their effectiveness remains challenging. Building on our previous findings that the expression of the antigen presenting molecule, HLA-DR, is crucial on tumor-infiltrating cytotoxic T lymphocytes (CTLs) for a favorable response to neoadjuvant c...
Zebrafish Avatar-test forecasts clinical response to chemotherapy in patients w...
Costa, Bruna; Estrada, Marta F.; Gomes, António; Fernandez, Laura M.; Azevedo, José M.; Póvoa, Vanda; Fontes, Márcia; Alves, António; Galzerano, AntónioCancer patients often undergo rounds of trial-and-error to find the most effective treatment because there is no test in the clinical practice for predicting therapy response. Here, we conduct a clinical study to validate the zebrafish patient-derived xenograft model (zAvatar) as a fast predictive platform for personalized treatment in colorectal cancer. zAvatars are generated with patient tumor cells, treated ...
Relapsed Ovarian Cancer patients with ascites and/or pleural effusion still ben...
Rebordão-Pires, Mariana; Estrada, Marta F.; Gomes, António; Silva, Filipa; Baptista, Carlota; Ramos, Maria João; Fortuna, Ana; Simões, Pedro) Background: Relapsed HGSOC with ascites and/or pleural effusion is a poor-prognostic population and poorly represented in clinical studies. We questioned if these patients are worth treating. In other words, if these patients received the most effective treatment, would it change the course of this disease? To our knowledge this is the first real-life study to evaluate this question in this low-survival popul...
Predictive and therapeutic implications of a novel PLCγ1/SHP2-driven mechanism ...
Duarte, Raquel; Rebelo de Almeida, Cátia; Negrão, Magda; Fernandes, Afonso; Borralho, Paula; Sobral, Daniel; Gallego-Paez, Lina M.; Machado, DanielPurpose: Cetuximab is an EGFR-targeted therapy approved for the treatment of RAS wild-type (WT) metastatic colorectal cancer (mCRC). However, about 60% of these patients show innate resistance to cetuximab. To increase cetuximab efficacy, it is crucial to successfully identify responder patients, as well as to develop new therapeutic approaches to overcome cetuximab resistance. Experimental design: We evaluated...
The role of hes genes in the controlled production of neurons
Fior, RitaCell–cell signalling mediated by the Notch pathway is essential for the spatial and temporal coordination of cellular behaviour in a variety of processes, from embryonic development and stem cell biology to disease. At the core of the Notch signalling pathway are the transmembrane Notch receptors and their ligands from the DSL ( D e lta– S e rrate– L a g-2) family. Upon ligand–receptor interaction, two proteoly...