2 documents found, page 1 of 1
Innate IFN-γ-Producing Cells Developing in the Absence of IL-2 Receptor Common ...
Resende, Mariana; Cardoso, Marcos S.; Ribeiro, Ana R.; Flórido, Manuela; Borges, Margarida; Castro, António G.; Alves, Nuno L.; Cooper, Andrea M.IFN-gamma is known to be predominantly produced by lymphoid cells such as certain subsets of T cells, NK cells, and other group 1 innate lymphoid cells. In this study, we used IFN-gamma reporter mouse models to search for additional cells capable of secreting this cytokine. We identified a novel and rare population of nonconventional IFN-gamma-producing cells of hematopoietic origin that were characterized by t...
Molecular and cellular mechanisms of Mycobacterium avium-induced thymic atrophy
Borges, Margarida; Silva, Palmira Conceição Araújo Barreira; Flórido, Manuela; Jordan, Michael B.; Neves, Margarida Correia; Appelberg, RuiThymic atrophy has been described as a consequence of infection by several pathogens and shown to be induced through diverse mechanisms. Using the mouse model of Mycobacterium avium infection, we show in this study that the production of NO from IFN-γ–activated macrophages plays a major role in mycobacterial infection-induced thymic atrophy. Our results show that disseminated infection with a highly virulent st...