3 documents found, page 1 of 1
Polymorphisms and haplotypes of TOLLIP and MUC5B are associated with susceptibi...
Mota, PC; Soares, ML; Ferreira, AC; Santos, RF; Cavaleiro Rufo, J; Vasconcelos, D; Carvalho, A; Guimarães, S; Vasques-Nóvoa, F; Cardoso, C; Melo, NIntroduction and Objectives: Hypersensitivity pneumonitis (HP) is an interstitial lung disease with diverse clinical features that can present a fibrotic phenotype similar to idiopathic pulmonary fibrosis (IPF) in genetically predisposed individuals. While several single nucleotide polymorphisms (SNPs) have been associated with IPF, the genetic factors contributing to fibrotic HP (fHP) remain poorly understood....
Development and validation of exhaled breath condensate microRNAs to identify a...
Mendes, FC; Paciência, I; Ferreira, AC; Martins, C; Rufo, JC; Silva, D; Cunha, P; Farraia, M; Moreira, P; Delgado, L; Soares, ML; Moreira, ADetection and quantification of microRNAs (miRNAs) in exhaled breath condensate (EBC) has been poorly explored. Therefore we aimed to assess miRNAs in EBC as potential biomarkers to diagnose and endotype asthma in school aged children. In a cross sectional, nested case control study, all the asthmatic children (n = 71) and a random sample of controls (n = 115), aged 7 to 12 years, attending 71 classrooms from 2...
Discovery of a small-molecule protein kinase Cd-selective activator with promis...
Bessa, C; Soares, J; Raimundo, L; Loureiro, J; Gomes, C; Reis, F; Soares, ML; Santos, D; Dureja, C; Chaudhuri, S; Lopez-Haber, C; Kazanietz, MProtein kinase C (PKC) isozymes play major roles in human diseases, including cancer. Yet, the poor understanding of isozymes-specific functions and the limited availability of selective pharmacological modulators of PKC isozymes have limited the clinical translation of PKC-targeting agents. Here, we report the first small-molecule PKCd-selective activator, the 7a-acetoxy-6ß-benzoyloxy-12-O-benzoylroyleanone (R...