5 documents found, page 1 of 1
Metallothionein expression in the central nervous system in response to chronic...
Navarro-Sempere, A.; Martínez-Peinado, P.; Rodrigues, A. S.; Garcia, Patrícia; Camarinho, R.; Grindlay, G.; Gras, L.; García, M.; Segovia, Y.ABSTRACT: It has been reported that volcanoes release several tonnes of mercury per year among other heavy metals through eruptions, fumaroles, or diffuse soil degassing. Since a high percentage of the world's population lives in the vicinity of an active volcano, the aim of this study is to evaluate the accumulation of these metals in the central nervous system and the presence of cellular mechanisms of heavy ...
Reactive astrogliosis in the dentate gyrus of mice exposed to active volcanic e...
Navarro-Sempere, Alicia; García, M.; Rodrigues, Armindo; Garcia, Patrícia; Camarinho, Ricardo; Segovia, YolandaAir pollution has been associated with neuroinflammatory processes and is considered a risk factor for the development of neurodegenerative diseases. Volcanic environments are considered a natural source of air pollution. However, the effects of natural source air pollution on the central nervous system (CNS) have not been reported, despite the fact that up to 10% of the world’s population lives near a historic...
First record on mercury accumulation in mice brain living in active volcanic en...
Navarro-Sempere, Alicia; Segovia, Yolanda; Rodrigues, Armindo; Garcia, Patrícia; Camarinho, Ricardo; García, M.The health effects of mercury vapor exposure on the brain in volcanic areas have not been previously addressed in the literature. However, 10% of the worldwide population inhabits in the vicinity of an active volcano, which are natural sources of elemental mercury emission. To evaluate the presence of mercury compounds in the brain after chronic exposure to volcanogenic mercury vapor, a histochemical study, usi...
Challenges for sustainable monitoring and evaluation of the EU Marine Strategy ...
Campuzano, F.; García, M.; Dabrowski, T.; Groom, S.; Ruiz-Villarreal, M.; Brotas, V.; Kaufmann, M.; Hartman, S.; Oliveira, P.; Martins, A.; Juliano, M.The European Atlantic Area in situ characterization/monitoring is challenging due to the high costs involved (24% of total EU waters for 12% of total population). The implementation of the EU Marine Strategy Framework Directive (MSFD) is complex if the objective is to extend periodic monitoring programs to offshore waters. Remote sensing and modelling have been recognised by the Copernicus Marine Service as sui...
Transancestral mapping and genetic load in systemic lupus erythematosus
Langefeld, C.; Ainsworth, H.; Cunninghame Graham, D.; Kelly, J.; Comeau, M.; Marion, M.; Howard, T.; Ramos, P.; Croker, J.; Morris, D.; Sandling, J.Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (∼50% of these regions have multiple independent association...