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Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocyto...

Rosado-Ramos, Rita; Poças, Gonçalo M.; Marques, Daniela; Foito, Alexandre; M Sevillano, David; Lopes-da-Silva, Mafalda; Gonçalves, Luís G.

Parkinson's Disease (PD) is a common neurodegenerative disorder affecting millions of people worldwide for which there are only symptomatic therapies. Small molecules able to target key pathological processes in PD have emerged as interesting options for modifying disease progression. We have previously shown that a (poly)phenol-enriched fraction (PEF) of Corema album L. leaf extract modulates central events in...


Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for...

Menezes, Regina; Foito, Alexandre; Jardim, Carolina; Costa, Inês; Garcia, Gonçalo; Rosado-Ramos, Rita; Freitag, Sabine; Alexander, Colin James

Funding: iNOVA4Health-UID/Multi/04462/2013, a program financially supported by Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement is acknowledged. This work was supported by Fundação para a Ciência e Tecnologia (IF/01097/2013 to C.N.S.), by The Scottish Government Rural and Environment Science and Analytical...


RNA-seq, de novo transcriptome assembly and flavonoid gene analysis in 13 wild ...

Thole, Vera; Bassard, Jean Etienne; Ramírez-González, Ricardo; Trick, Martin; Ghasemi Afshar, Bijan; Breitel, Dario; Hill, Lionel; Foito, Alexandre

This research was funded by the European Union Framework Program 7, Project BacHBerry [FP7–613793]. The authors also acknowledge support from the Institute Strategic Programmes ‘Designing Future Wheat’ (BB/P016855/1), ‘Understanding and Exploiting Plant and Microbial Secondary Metabolism’ (BB/J004596/1) and ‘Molecules from Nature’ (BB/P012523/1) from the UK Biotechnology and Biological Sciences Research Council...


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