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Epigallocatechin-3-gallate PEGylated poly(lactic-co-glycolic) acid nanoparticle...

Cano, Amanda; Ettcheto, Miren; Espina, Marta; Auladell, Carmen; Folch, Jaume; Kühne, Britta A; Barenys, Marta; Sánchez-López, Elena; Souto, Eliana B.

Aim: To compare free and nanoparticle (NP)-encapsulated epigallocatechin-3-gallate (EGCG) for the treatment of Huntingtons disease (HD)-like symptoms in mice. Materials \& methods: EGCG was incorporated into PEGylated poly(lactic-co-glycolic) acid NPs with ascorbic acid (AA). HD-like striatal lesions and motor deficit were induced in mice by 3-nitropropionic acid-intoxication. EGCG and EGCG/AA NPs were co-admin...

Date: 2020   |   Origin: RepositóriUM - Universidade do Minho
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