23 documents found, page 1 of 3
Crosslinked poly(hydroxyurethane) films from biobased carbonates: Structure-pro...
Frias, Célia F.; Fonseca, Ana C.; Coelho, Jorge F. J.; Serra, ArménioIn this work, crosslinked poly(hydroxyurethane) (PHU) films were prepared by the reaction of biobased cyclic carbonates (BisCC), with different chain lengths, with hyperbranched poly(ethyleneimine) (PEI) under amenable conditions and in the absence of catalysts. Fourier transform infrared (FTIR) spectroscopy revealed that the carbonate groups were completely consumed in the crosslinking reaction and the gel con...
Nanotechnology-based techniques for hair follicle regeneration
Correia, Mafalda Andreia Leite; Lopes, Joana; Lopes, Daniela; Melero, Ana; Makvandi, Pooyan; Veiga, Francisco; Coelho, Jorge F. J.; Fonseca, Ana C.The hair follicle (HF) is a multicellular complex structure of the skin that contains a reservoir of multipotent stem cells. Traditional hair repair methods such as drug therapies, hair transplantation, and stem cell therapy have limitations. Advances in nanotechnology offer new approaches for HF regeneration, including controlled drug release and HF-specific targeting. Until recently, embryogenesis was thought...
In Vitro Evaluation of Biphasic Calcium Phosphate Scaffolds Derived from Cuttle...
Pereira, Patrícia; Neto, Ana S.; Rodrigues, Ana Sofia; Barros, Inês; Miranda, Catarina O.; Santos, João Ramalho; Almeida, Luís Pereira deThis study investigates the osteogenic differentiation of umbilical-cord-derived human mesenchymal stromal cells (hUC-MSCs) on biphasic calcium phosphate (BCP) scaffolds derived from cuttlefish bone doped with metal ions and coated with polymers. First, the in vitro cytocompatibility of the undoped and ion-doped (Sr2+, Mg2+ and/or Zn2+) BCP scaffolds was evaluated for 72 h using Live/Dead staining and viability...
HLA‐A23/HLA‐A24 serotypes and dementia interaction in the elderly: Association ...
Cardoso, Elsa M.; Gomes, Vânia Lourenço; Esgalhado, André J.; Ferreira, Débora Reste; Oliveira, Nádia; Amaral, Ana Saraiva; Martinho, AntónioMHC class I molecules regulate brain development and plasticity in mice and HLA class I molecules are associated with brain disorders in humans. We investigated the relationship between plasma-derived soluble human HLA class I molecules (sHLA class I), HLA class I serotypes and dementia. A cohort of HLA class I serotyped elderly subjects with no dementia/predementia (NpD, n = 28), or with dementia (D, n = 28) w...
Structural, thermal, and mechanical characterisation of PEEK-based composites i...
Nikonovich, Maksim; Costa, Joana F. S.; Fonseca, Ana C.; Ramalho, Amílcar; Emami, NazaninThermal, thermo-mechanical and mechanical properties of four different commercially available polyetheretherketones (PEEK) based materials were investigated. PEEK matrix was either modified and/or reinforced with carbon fibres, graphite and/or PTFE. Impact strength was measured at three different temperatures: 25 ◦C, 100 ◦C, and 195 ◦C. At 25 ◦C, thermal stability and mechanical properties, including the elasti...
Isosorbide and 2,5-Furandicarboxylic Acid Based (Co)Polyesters: Synthesis, Char...
Bouyahya, Chaima; Patrício, Rafael; Paço, Ana; Lima, Mafalda S.; Fonseca, Ana C.; Rocha-Santos, Teresa; Majdoub, Mustapha; Silvestre, Armando J.D.Poly(2,5-furandicarboxylate)s incorporating aliphatic moieties represent a promising family of polyesters, typically entirely based on renewable resources and with tailored properties, notably degradability. This study aims to go beyond by developing poly(isosorbide 2,5-furandicarboxylate-co-dodecanedioate) copolyesters derived from isosorbide (Is), 2,5-furandicarboxylic acid (FDCA), and 1,12-dodecanedioic acid...
Highly Porous Composite Scaffolds Endowed with Antibacterial Activity for Multi...
Neto, Ana S.; Pereira, Patrícia; Fonseca, Ana C.; Dias, Carla; Almeida, Mariana C.; Barros, Inês; Miranda, Catarina O.; Almeida, Luís P. deThe present study deals with the development of multifunctional biphasic calcium phosphate (BCP) scaffolds coated with biopolymers—poly("-caprolactone) (PCL) or poly(ester urea) (PEU)—loaded with an antibiotic drug, Rifampicin (RFP). The amounts of RFP incorporated into the PCL and PEU-coated scaffolds were 0.55 0.04 and 0.45 0.02 wt%, respectively. The in vitro drug release profiles in phosphate buffered salin...
Is parental psychological flexibility a (uni) dimensional construct? A bifactor...
Fonseca, Ana C.; Canavarro, Maria Cristina; Moreira, HelenaThis study aimed to examine the (uni) dimensionality of the Parental Acceptance Questionnaire (6-PAQ) in a sample of Portuguese parents of children within the community using a bifactor model that can test the separate contribution of the dimensions and of the general score. 390 parents of children (1–11 years) recruited online and in-person completed the assessment protocol, including the 6 PAQ and other measu...
A Preliminary Evaluation of the Pro-Chondrogenic Potential of 3D-Bioprinted Pol...
Moxon, Samuel R.; Ferreira, Miguel J. S.; Santos, Patrícia dos; Popa, Bogdan; Gloria, Antonio; Katsarava, Ramaz; Tugushi, David; Serra, Arménio C.Degeneration of articular cartilage (AC) is a common healthcare issue that can result in significantly impaired function and mobility for affected patients. The avascular nature of the tissue strongly burdens its regenerative capacity contributing to the development of more serious conditions such as osteoarthritis. Recent advances in bioprinting have prompted the development of alternative tissue engineering t...
Brief Overview on Bio-Based Adhesives and Sealants
Magalhães, Solange; Alves, Luís; Medronho, Bruno; Fonseca, Ana C.; Romano, Anabela; Coelho, Jorge F. J.; Norgren, MagnusAdhesives and sealants (AS) are materials with excellent properties, versatility, and simple curing mechanisms, being widely used in different areas ranging from the construction to the medical sectors. Due to the fast-growing demand for petroleum-based products and the consequent negative environmental impact, there is an increasing need to develop novel and more sustainable sources to obtain raw materials (mo...