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One-Pot Microfluidics to Engineer Chitosan Nanoparticles Conjugated with Antimi...

Fonseca, D R; Alves, PM; Neto, E; Custodio, B; Guimaraes, S; Moura, D; Annis, F; Martins, M; Gomes, A; Teixeira, C; Gomes, P; Pereira, RF; Freitas, P

Surface bioconjugation of antimicrobial peptides (AMP) onto nanoparticles (AMP-NP) is a complex, multistep, and time-consuming task. Herein, a microfluidic system for the one-pot production of AMP-NP was developed. Norbornene-modified chitosan was used for NP production (NorChit-NP), and thiolated-AMP was grafted on their surface via thiol-norbornene "photoclick" chemistry over exposure of two parallel UV LEDs....

Date: 2024   |   Origin: Repositório Aberto da Universidade do Porto
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