4 documents found, page 1 of 1
Bacterial nanocellulose-hyaluronic acid microneedle patches for skin applicatio...
Fonseca, Daniela F. S.; Vilela, Carla; Pinto, Ricardo J. B.; Bastos, Verónica; Oliveira, Helena; Catarino, José; Faísca, Pedro; Rosado, CatarinaThe aim of the present study was to develop innovative patches for dermo-cosmetic applications based on dissolvable hyaluronic acid (HA) microneedles (MNs) combined with bacterial nanocellulose (BC) as the back layer. HA was employed as an active biomacromolecule, with hydrating and regenerative properties and volumizing effect, whereas BC was used as support for the incorporation of an additional bioactive mol...
Pullulan microneedle patches for the efficient transdermal administration of in...
Fonseca, Daniela F. S.; Costa, Paulo C.; Almeida, Isabel F.; Dias-Pereira, Patrícia; Correia-Sá, Inês; Bastos, Verónica; Oliveira, HelenaThe present study reports the fabrication of dissolvable microneedle (MN) patches using pullulan (PL), a water-soluble polysaccharide with excellent film-forming ability, for the transdermal administration of insulin, envisioning the non-invasive treatment of diabetes. PL MNs patches were successfully prepared by micromoulding and revealed good thermal stability (Tdmax = 294 °C) and mechanical properties (>0.15...
A compendium of current developments on polysaccharide and protein-based micron...
Fonseca, Daniela F. S.; Vilela, Carla; Silvestre, Armando J. D.; Freire, Carmen S. R.Microneedles (MNs), i.e. minimally invasive three-dimensional microstructures that penetrate the stratum corneum inducing relatively little or no pain, have been studied as appealing therapeutic vehicles for transdermal drug delivery. Over the last years, the fabrication of MNs using biopolymers, such as polysaccharides and proteins, has sparked the imagination of scientists due to their recognized biocompatibi...
Bioactive Phytochemicals from Wild Arbutus unedo L. Berries from Different Loca...
Fonseca, Daniela F. S.; Salvador, Angelo C.; Santos, Sonia A. O.; Vilela, Carla; Freire, Carmen S. R.; Silvestre, Armando J. D.; Rocha, Silvia M.The lipophilic composition of wild Arbutus unedo L. berries, collected from six locations in Penacova (center of Portugal), as well as some general chemical parameters, namely total soluble solids, pH, titratable acidity, total phenolic content and antioxidant activity was studied in detail to better understand its potential as a source of bioactive compounds. The chemical composition of the lipophilic extracts...