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The diagnostic and prognostic role of liquid-based cytology: are we ready to mo...

Rossi, Esther Diana; Bizzarro, Tommaso; Longatto Filho, Adhemar; Gerhard, Rene; Schmitt, Fernando

Here, we evaluate the diagnostic and prognostic role of liquid-based cytology (LBC) in different body lesions, including thyroid, lung, effusions and malignant breast lesions. LBC has gained consensus after being applied to both non-gynecologic and fine-needle aspiration cytology. Although some remain sceptical regarding the diagnostic efficacy of LBC, mainly when used alone, in recent years, good results have ...


P-cadherin functional role is dependent on E-cadherin cellular context: a proof...

Ribeiro, Ana Sofia; Sousa, Bárbara; Carreto, Laura; Mendes, Nuno; Nobre, Ana Rita; Ricardo, Sara; Albergaria, André; Cameselle-Teijeiro, Jorge F.

P-cadherin overexpression is associated with worse breast cancer survival, being a poor prognostic marker as well as a putative therapeutic target for the aggressive triple-negative and basal-like carcinomas (TNBCs). Previously, we have shown that P-cadherin promotes breast cancer invasion of cells where membrane E-cadherin was maintained; however, it suppresses invasion in models without endogenous cadherins, ...


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