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Surveillance of multiple congenital anomalies; searching for new associations

Morris, Joan K.; Bergman, Jorieke E.H.; Barisic, Ingeborg; Wellesley, Diana; Tucker, David; Limb, Elizabeth; Addor, Marie-Claude

Many human teratogens are associated with a spectrum of congenital anomalies rather than a single defect, and therefore the identification of congenital anomalies occurring together more frequently than expected may improve the detection of teratogens. Thirty-two EUROCAT congenital anomaly registries covering 6,599,765 births provided 123,566 cases with one or more major congenital anomalies (excluding chromoso...


Prevalence of vascular disruption anomalies and association with young maternal...

Morris, Joan K.; Wellesley, Diana; Limb, Elizabeth; Bergman, Jorieke E.H.; Kinsner‐Ovaskainen, Agnieszka; Addor, Marie Claude; Broughan, Jennifer M.

Background: Younger mothers are at a greater risk of having a pregnancy with gastroschisis and the risk is higher in the United Kingdom than other European countries. Gastroschisis is thought to be a vascular disruption anomaly and the aim of this study was to analyze the prevalence of other possible vascular disruption anomalies to determine whether both the younger maternal age and the UK associations also oc...


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