39 documents found, page 1 of 4
Diagnosis and management of acromegaly: a consensus statement of the pituitary ...
Cardoso, Luís Miguel; Marques, Pedro; Pereira, Maria Teresa; Agapito, Ana; Almeida, Rui; Amaral, Sara; Cattoni, Maria Begona; Bugalho, Maria JoãoAcromegaly is characterised by hypersecretion of growth hormone and presents diagnostic and therapeutic challenges that require consensus and guidelines for effective management. The Pituitary Study Group of the Portuguese Society of Endocrinology, Diabetes and Metabolism used a modified Delphi methodology to develop consensus recommendations for the diagnosis and management of acromegaly. A multidisciplinary p...
Functional Outcomes of Basilar Thumb Arthritis Treatment with Tendon Suspension...
Buruian, Alexei; Buruian, Alexei; Hugo Pinheiro , Vítor; Néri , António; Matos , Pedro; Marques, Alexandre; Fonseca, FernandoIntroduction: Thumb arthritis is a common condition. Its prevalence increases with age and predominantly affects females. Methods: In the period from January 2009 to December 2014, 105 patients were submitted to trapezectomy, ligament reconstruction and tendon interposition for basilar thumb arthritis grades III and IV, of which 40 patients (42 hands) were included in the study. The majority, 92.5%, were fema...
Natural Distribution of the Femoral Mechanical Anatomical Angle in a Portuguese...
Buruian, Alexei; Buruian, Alexei; Homem, Emanuel; Modesto, Gonçalo; Mendes , João; Alegre, Carlos; Fonseca, FernandoIntroduction: Total knee arthroplasty is one of the most successful interventions in medicine. Mechanical alignment remains the gold standard in obtaining a proper coronal prosthetic alignment. There is controversy regarding the use of a fixed cutting angle of the distal femur, with a value between 4o‐7° of valgus that is frequently used intraoperatively. The aim of this study was to describe the distribution o...
Genetic Architecture of Congenital Hypogonadotropic Hypogonadism: Insights from...
Carriço, Josianne Nunes; Gonçalves, Catarina Inês; Al-Naama, Asma; Syed, Najeeb; Aragüés, José Maria; Bastos, Margarida; Fonseca, FernandoStudy question: What is the contribution of genetic defects in Portuguese patients with congenital hypogonadotropic hypogonadism (CHH)? Summary answer: Approximately one-third of patients with CHH were found to have a genetic cause for their disorder, with causal pathogenic and likely pathogenic germline variants distributed among 10 different genes; cases of oligogenic inheritance were also included. What is k...
Avaliação de diferenças bioquímicas entre indivíduos diabéticos com e sem varia...
Vaz, Margarida; Gaspar, Gisela; Agapito, Ana; Neves, Ana Carolina; Bogalho, Ana Paula; Almeida, Bruno; Pereira, Carla; Fonseca, FernandoA diabetes tipo MODY (Maturity-onset diabetes of the young) é um tipo de diabetes causada por mutações em um único gene. Existe 14 genes associados a essa doença, no entanto, a maioria dos casos de MODY é causada por alterações nos genes GCK, HNF1A, HNF1B e HNF4A. Cada subtipo desta patologia apresenta características fenotípicas, metabólicas e complicações para a saúde distintas o que exige uma adequação terap...
Impact of educational gardens and workshop activities on 8th-Grade student’s pe...
Azevedo, Herlander; Soares-Silva, Isabel; Fonseca, Fernando; Alves, Paulo; Silva, Duarte; Azevedo, Maria-ManuelEducational gardens can be a significant resource in the promotion of environmental education, engaging both the school population and the general public. The main goal of the present study was to implement and assess a hands-on interventional program to promote knowledge and awareness of plant-related topics at a basic school level. We report on a hands-on educational project implemented with 8th-grade Portugu...
Walkable cities: using the Smart Pedestrian Net Method for evaluating a pedestr...
Fonseca, Fernando; Fernandes, Escolástica; Ramos, Rui A. R.Evidence for the benefits of walking has attracted the attention of researchers and practitioners and encouraged them to develop healthier and more sustainable walkable cities. Many methods and approaches have been developed to measure walkability; namely, by using land use attributes. This paper examines the transferability of the Geographic Information System (GIS) based multi-criteria method developed in the...
Estudo molecular da diabetes tipo MODY: atualização de resultados (2011-2019)
Vaz, Margarida; Gaspar, Gisela; Agapito, Ana; Neves, Ana Carolina; Bogalho, Ana Paula; Almeida, Bruno; Pereira, Carla; Fonseca, FernandoA diabetes tipo MODY é uma doença monogénica que se estima que contribua para 1 a 5% de todos os casos de diabetes. Atualmente existem 14 genes associados a esta patologia cujos doentes apresentam características fenotípicas, metabólicas e genéticas muito heterogéneas. Em 2011, o Departamento de Promoção da Saúde e Prevenção de Doenças Não Transmissíveis do Instituto Nacional de Saúde Doutor Ricardo Jorge imple...
Tibial plateau fractures osteosynthesis—a case series of 88 patients evaluating...
Mónico, José Lito dos Santos; Andrade, Renato; Matos, Pedro; Mónico, Lisete; Mariano, João Cura; Espregueira-Mendes, João; Fonseca, FernandoBackground: Tibial plateau fractures can be treated using different surgical approaches and different fixation methods. With multiple surgical options available, optimal treatment is still controversial. With variable results, surgical osteosynthesis remains challenging, being the choice of appropriate fixation method fundamental for a favourable clinical outcome. Our goal is to analyse the surgical outcomes of...
Impacts of low-frequency noise from industrial sources in residential areas
Silva, Lígia Torres; Magalhães, Alda; Silva, J. F.; Fonseca, FernandoThe World Health Organisation classifies Low-frequency noise (LFN) as an environmental problem that causes various health impacts. Industrial sites and activities are among the various identified sources of LFN. However, industrial noise has been more studied on higher frequencies than lower frequencies. To fill this gap, this paper evaluates the impacts of LFN emitted by industrial sources in neighbouring resi...