4 documents found, page 1 of 1
Anxiety and depression in patients with giant cell arteritis
Martinho, Joana Martins; Ponte, André; Dourado, Eduardo; Khmelinskii, Nikita; Barreira, Sofia C.; Machado, Ana R. Cruz; Macieira, Carla; Teixeira, VítorObjectives To compare the prevalence of anxiety and depression in patients with GCA with that in the general population, using the Hospital Anxiety and Depression Scale (HADS), and to identify independent predictors of these psychiatric manifestations in patients with GCA.Methods We conducted a cross-sectional study including all patients diagnosed with GCA followed during 1 year in a vasculitis outpatient clin...
Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
Cascão, Rita; Fonseca, João E.; Moita, Luis F.The identification of new bioactive compounds derived from medicinal plants with significant therapeutic properties has attracted considerable interest in recent years. Such is the case of the Tripterygium wilfordii (TW), an herb used in Chinese medicine. Clinical trials performed so far using its root extracts have shown impressive therapeutic properties but also revealed substantial gastrointestinal side effe...
Decrease of CD68 Synovial Macrophages in Celastrol Treated Arthritic Rats
Cascão, Rita; Vidal, Bruno; Lopes, Inês P.; Paisana, Eunice; Rino, José; Moita, Luis F.; Fonseca, João E.Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease characterized by cellular infiltration into the joints, hyperproliferation of synovial cells and bone damage. Available treatments for RA only induce remission in around 30% of the patients, have important adverse effects and its use is limited by their high cost. Therefore, compounds that can control arthritis, with an acceptable safet...
Think Tank: Relatório Estratégico sobre Publicação Científica Biomédica em Port...
Marinho, Rui T.; Donato, Helena; Fernandez-Llimos, Fernando; Massano, João; Silva, Jose M.; Almeida, Miguel; Carvalho, Jose C.; Villanueva, Tiago