6 documents found, page 1 of 1
Mycobacterium tuberculosis infection up-regulates sialyl lewis x expression in ...
Matos, R; Fonseca, KL; Mereiter, S; Maceiras, AR; Gomes, J; Vilaplana, C; Gärtner, F; Rodrigues, P; Reis, CA; Saraiva, M; Magalhães, AGlycans display increasingly recognized roles in pathological contexts, however, their impact in the host-pathogen interplay in many infectious diseases remains largely unknown. This is the case for tuberculosis (TB), one of the ten most fatal diseases worldwide, caused by infection of the bacteria Mycobacterium tuberculosis. We have recently reported that perturbing the core-2 O-glycans biosynthetic pathway in...
Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic...
Sousa, J; Cá, B; Maceiras, AR; Simões-Costa, L; Fonseca, KL; Fernandes, AI; Ramos, A; Carvalho, T; Barros, L; Magalhães, C; Chiner-Oms, Á; Machado, HGenetic diversity of Mycobacterium tuberculosis affects immune responses and clinical outcomes of tuberculosis (TB). However, how bacterial diversity orchestrates immune responses to direct distinct TB severities is unknown. Here we study 681 patients with pulmonary TB and show that M. tuberculosis isolates from cases with mild disease consistently induce robust cytokine responses in macrophages across multiple...
Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic...
Sousa, J; Cá, B; Maceiras, AR; Simões-Costa, L; Fonseca, KL; Fernandes, AI; Ramos, A; Carvalho, T; Barros, L; Magalhães, C; Chiner-Oms, Á; Machado, HGenetic diversity of Mycobacterium tuberculosis affects immune responses and clinical outcomes of tuberculosis (TB). However, how bacterial diversity orchestrates immune responses to direct distinct TB severities is unknown. Here we study 681 patients with pulmonary TB and show that M. tuberculosis isolates from cases with mild disease consistently induce robust cytokine responses in macrophages across multiple...
Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neu...
Moreira-Teixeira, L; Stimpson, PJ; Stavropoulos, E; Hadebe, S; Chakravarty, P; Ioannou, M; Aramburu, IV; Herbert, E; Priestnall, SL; Suarez-Bonnet, ATuberculosis (TB) is a leading cause of mortality due to infectious disease, but the factors determining disease progression are unclear. Transcriptional signatures associated with type I IFN signalling and neutrophilic inflammation were shown to correlate with disease severity in mouse models of TB. Here we show that similar transcriptional signatures correlate with increased bacterial loads and exacerbate pat...
Experimental Evidence for Limited in vivo Virulence of Mycobacterium africanum
Cá, B; Fonseca, KL; Sousa, J; Maceiras, AR; Machado, D; Sanca, L; Rabna, P; Rodrigues, P; Viveiros, M; Saraiva, MTuberculosis remains a public health problem and a main cause of death to humans. Both Mycobacterium tuberculosis and Mycobacterium africanum cause tuberculosis. In contrast to M. tuberculosis, which is geographically spread, M. africanum is restricted to West Africa. Differences have also been found in the growth rate and type of disease caused by M. africanum, globally suggesting an attenuation of this bacter...
Experimental Study of Tuberculosis: From Animal Models to Complex Cell Systems ...
Fonseca, KL; Rodrigues, PS; Olsson, IAS; Saraiva, MTuberculosis (TB) is a devastating disease to mankind that has killed more people than any other infectious disease. Despite many efforts and successes from the scientific and health communities, the prospect of TB elimination remains distant. On the one hand, sustainable public health programs with affordable and broad implementation of anti-TB measures are needed. On the other hand, achieving TB elimination r...