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In Situ Near-Infrared (NIR) Versus High-Throughput Mid- Infrared (MIR) Spectros...

Sales, Kevin C.; Rosa, Filipa; Sampaio, Pedro N.; Fonseca, LuÍs P.; B. Lopes, Marta; Calado, Cecília

The development of biopharmaceutical manufacturing processes presents critical constraints, with the major constraint being that living cells synthesize these molecules, presenting inherent behavior variability due to their high sensitivity to small fluctuations in the cultivation environment. To speed up the development process and to control this critical manufacturing step, it is relevant to develop high-thr...


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