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Active immunization against hepatitis B virus (HBV) with low-doses of plasma-de...
Carrilho, Flair José; Queiroz, Maria Lúcia; Silva, Luiz Caetano da; Fonseca, Luís Edmundo Pinto da; Granato, Celso; Oba, Isabel; Obara, LedaSchedule for vaccination against HBV infection has usually been based on three separate injections of 20 meg of the vaccine by intramuscular route. One of the main shortcomings to its use in large scale programs has been its high cost. Ninety out of 300 health workers were submitted to three injections of 2 meg of plasma-derived vaccine (PDV) by intradermal (ID) route on days 0, 30, and 180. Anti-HBs was detect...
Comparação dos marcadores sorológicos da replicação do vírus da hepatite B: est...
Pinho, João Renato Rebello; Fonseca, Luís Edmundo Pinto da; Song, Yu; Miyamoto, Yuriko; Carrilho, Flair José; Granato, Celso Francisco HernandesThe detection of HBV-DNA in serum by molecular hybridization is the most sensitive and specific marker of replication and infectivity of hepatitis B virus and currently is proposed as a routine diagnostic technique in the follow-up of HBV - related diseases. Comparing different techniques already described, we found that direct spotting of serum samples on nitrocellulose membranes under vacuum filtration, follo...