29 documents found, page 1 of 3

Assessing response to stressful emotions: a controlled crossover study using pu...

"Background: Fear and horror induce autonomic protective responses, acting as ""survival intelligence."" Pupillometry is an innovative method that captures real-time autonomic nervous system reactions to stress. Objective: To evaluate the feasibility of pupillometry to assess the acute response to a passive real-life stressor-viewing a truthful war scene. Methods: Thirteen medical students (10 women) with an av...

LOCUS (LOng Covid–Understanding Symptoms, events and use of services in Portuga...

Approximately 10% of patients experience symptoms of Post COVID-19 Condition (PCC) after a SARS-CoV-2 infection. Akin acute COVID-19, PCC may impact a multitude of organs and systems, such as the cardiovascular, respiratory, musculoskeletal, and neurological systems. The frequency and associated risk factors of PCC are still unclear among both community and hospital settings in individuals with a history of COV...

Evaluation of the antitumour and antiproliferative effect of xanthohumol-loaded...

Cutaneous melanoma is the deadliest type of skin cancer and current treatment is still inadequate, with low patient survival rates. The polyphenol xanthohumol has been shown to inhibit tumourigenesis and metastasization, however its physicochemical properties restrict its application. In this work, we developed PLGA nanoparticles encapsulating xanthohumol and tested its antipro-liferative, antitumour, and migra...

CYP21A2 Gene Pathogenic Variants: A Multicenter Study on Genotype-Phenotype Cor...

BACKGROUND: Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) is an autosomal recessive disorder characterized by 3 overlapping phenotypes: salt-wasting (SW), simple virilizing (SV), and non-classic (NC). We aimed at conducting a nationwide genotype description of the CAH pediatric patients and to establish their genotype-phenotype correlation. METHODS: CAH patients were recruited fr...

SRC inhibition prevents P-cadherin mediated signaling and function in basal-lik...

BACKGROUND: Basal-like breast cancer (BLBC) is a poor prognosis subgroup of triple-negative carcinomas that still lack specific target therapies and accurate biomarkers for treatment selection. P-cadherin is frequently overexpressed in these tumors, promoting cell invasion, stem cell activity and tumorigenesis by the activation of Src-Family kinase (SRC) signaling. Therefore, our aim was to evaluate if the trea...

Experimental protocol for kinematic analysis of the hand during the use of uppe...

Síndrome de Schnitzler

Síndrome Pulmão-Rim

Perinatal Neuroblastoma – A Challenge for the Neonatologist

O neuroblastoma é o tumor maligno mais frequente no período neonatal. O diagnóstico pré-natal tem aumentado devido à qualidade da ecografia obstétrica, que permite a deteção de formações de pequenas dimensões nas glândulas suprarrenais. Apresentam-se os casos clínicos de quatro recém‑nascidos com o diagnóstico de neuroblastoma perinatal. Dois recém-nascidos apresentaram imagens quísticas pré-natais na suprarren...

A Influência do Ensino Pré-Operatório de Enfermagem na Redução da Ansiedade Int...

O ensino pré-operatório inicia-se com o acolhimento do cliente, sendo este um processo contínuo, dinâmico e favorável ao desenvolvimento de uma relação de ajuda. Todas as pessoas que são submetidas a uma cirurgia deparam-se com sintomas como medo, insegurança e ansiedade face ao desconhecido (Dugas, 1984). O ensino pré-operatório é o meio que o enfermeiro tem ao dispor para fazer face a esta sintomatologia apre...