6 documents found, page 1 of 1
RAG Recombinase as a Selective Pressure for Genome Evolution
Passagem-Santos, D.; Bonnet, M.; Sobral, D.; Trancoso, I.; Silva, J.G.; Barreto, V.M.; Athanasiadis, A.; Demengeot, J.; Pereira-Leal, J.B.The RAG recombinase is a domesticated transposable element co-opted in jawed vertebrates to drive the process of the so-called V(D)J recombination, which is the hallmark of the adaptive immune system to produce antigen receptors. RAG targets, namely, the Recombination Signal Sequences (RSS), are rather long and degenerated sequences, which highlights the ability of the recombinase to interact with a wide range ...
Proinsulin multi-peptide immunotherapy induces antigen-specific regulatory T ce...
Gibson, V. B.; Nikolic, T.; Pearce, V. Q.; Demengeot, J.; Roep, B. O.; Peakman, M.Peptide immunotherapy (PIT) is a targeted therapeutic approach, involving administration of disease-associated peptides, with the aim of restoring antigen-specific immunological tolerance without generalized immunosuppression. In type 1 diabetes, proinsulin is a primary antigen targeted by the autoimmune response, and is therefore a strong candidate for exploitation via PIT in this setting. To elucidate the opt...
Compensatory T-Cell Regulation in Unaffected Relatives of SLE Patients, and Opp...
Fesel, C.; Barreto, M.; Ferreira, R.C.; Costa, N.; Venda, L.L.; Pereira, C.; Carvalho, C.; Morães-Fontes, M.F.; Ferreira, C.M.; Vasconcelos, C.In human systemic lupus erythematosus (SLE), diverse autoantibodies accumulate over years before disease manifestation. Unaffected relatives of SLE patients frequently share a sustained production of autoantibodies with indiscriminable specificity, usually without ever acquiring the disease. We studied relations of IgG autoantibody profiles and peripheral blood activated regulatory T-cells (aTregs), represented...
Low frequency of CD4+CD25+ Treg in SLE patients: a heritable trait associated w...
Barreto, M.; Ferreira, R.; Lourenço, L.; Moraes-Fontes, M.; Santos, E.; Alves, M.; Carvalho, C.; Martins, B.; Andreia, R.; Viana, J.; Vasconcelos, C.Abstract BACKGROUND: CD4+CD25+ regulatory T cells play an essential role in maintaining immune homeostasis and preventing autoimmunity. Therefore, defects in Treg development, maintenance or function have been associated with several human autoimmune diseases including Systemic Lupus Erythematosus (SLE), a systemic autoimmune disease characterized by loss of tolerance to nuclear components and significantly mor...
Low frequency of CD4+CD25+ Treg in SLE patients: a heritable trait associated w...
Barreto, M.; Ferreira, R.C.; Lourenço, L.; Moraes-Fontes, M.F.; Santos, E.; Alves, M.; Carvalho, C.; Martins, B.; Andreia, R.; Viana, J.F.CD4+CD25+ regulatory T cells play an essential role in maintaining immune homeostasis and preventing autoimmunity. Therefore, defects in Treg development, maintenance or function have been associated with several human autoimmune diseases including Systemic Lupus Erythematosus (SLE), a systemic autoimmune disease characterized by loss of tolerance to nuclear components and significantly more frequent in females...
Low frequency of CD4(+) CD25(+) Treg in SLE patients: a heritable trait associa...
Barreto, M.; Ferreira, RC.; Lourenço, L.; Moraes-Fontes, MF.; Santos, E.; Alves, M.; Carvalho, C.; Martins, B.; Andreia, R.; Viana, JF.; Vasconcelos, C.Background: CD4(+)CD25(+) regulatory T cells play an essential role in maintaining immune homeostasis and preventing autoimmunity. Therefore, defects in Treg development, maintenance or function have been associated with several human autoimmune diseases including Systemic Lupus Erythematosus (SLE), a systemic autoimmune disease characterized by loss of tolerance to nuclear components and significantly more fre...