10 documents found, page 1 of 1
Phenotype-Genotype Correlation in Colorectal Cancer: A Real-Life Study
Frias-Gomes,Catarina; Sousa,Ana Carla; Rolim,Inês; Henriques,Ana Raquel; Branco,Francisco; Janeiro,André; Malveiro,Sara; Dário,Ana RitaAbstract Background and Aims: Colorectal cancer (CRC) is a heterogeneous disease with distinctive genetic pathways, such as chromosomal instability, microsatellite instability and methylator pathway. Our aim was to correlate clinical and genetic characteristics of CRC patients in order to understand clinical implications of tumour genotype. Methods: Single-institution retrospective cohort of patients who underw...
Valor Prognóstico de Níveis Elevados de Troponina I Isolados em Pacientes sem S...
Domingues,Célia; Ferreira,Maria João Vidigal; Ferreira,Joana Moura; Marinho,Ana Vera; Alves,Patrícia Marques; Ferreira,Cátia; Fonseca,IsabelResumo Fundamento: Embora a elevação não isquêmica da troponina seja frequentemente observada em pacientes admitidos no pronto-socorro (PS), não há consenso quanto ao seu manejo. Objetivos: Este estudo teve como objetivo caracterizar os pacientes admitidos no PS com elevação da troponina não-isquêmica e identificar potenciais preditores de mortalidade nessa população. Métodos: Este estudo observacional retrospe...
Validation of a model to predict six-month mortality in incident elderly dialys...
Santos,Josefina; Oliveira,Pedro; Malheiro,Jorge; Campos,Andreia; Correia,Sofia; Cabrita,António; Lobato,Luísa; Fonseca,IsabelBackground and objectives: To evaluate RRT benefits and risks and to inform patients and their families about ESRD treatment options, we have developed a prognostic score to predict 6-month mortality in elderly ESRD patients initiating dialysis. Five independent predictors were identified and a point system was constructed: age 75 years or older (2 points), coronary artery disease (2 points), cerebrovascular di...
Demographic, clinical characteristics and cardiovascular disease burden in a Po...
Lascasas,Josefina Maria Sousa Santos; Fonseca,Isabel; Malheiro,Jorge; Santos,Sofia; Campos,Andreia; Castro,Ana; Moreira,Carla; Correia,SofiaABSTRACT Introduction: Chronic kidney disease (CKD) is an independent risk factor for several unfavorable outcomes including cardiovascular disease (CVD), particularly in the elderly, who represent the most rapidly growing segment of the end-stage kidney disease (ESKD) population. Portugal has the highest European unadjusted incidence and prevalence rates of ESKD. In 2012, we started to follow a cohort of elder...
Color doppler ultrasound assessment of juxta-anastomotic stenosis in radiocepha...
Pimentel,Ana; Almeida,Paulo; de Matos,Norton; Loureiro,Luís; Teixeira,Gabriela; Rego,Duarte; Teixeira,Sérgio; Pinheiro,Joaquim; Fonseca,IsabelBackground: Juxta-anastomotic stenosis (JAS) is a common complication of radiocephalic arteriovenous fistulas. There is diverging data as to the best therapeutic approach being angioplasty or surgery. Pre-operative color Doppler ultrasound (CDU) is accurately used for initial assessment of the vascular access and follow-up monitoring. The aim of this study was to evaluate immediate and long-term results of endo...
Infectious risk of elderly patients on peritoneal dialysis: Experience of a por...
Belino,Carolina L; Barreto,Patrícia S; Santos,Maria C; Gomes,Ana M; Fonseca,Isabel; Fernandes,João CBackground: The goal of this study was to compare the risk of peritoneal dialysis-related infections in younger and older patients and to identify risk factors for infection in elderly patients. Methods: We performed a longitudinal retrospective study on a population of Portuguese peritoneal dialysis patients treated at the same center between January 2005 and December 2015. Clinical and laboratory data were co...
Fgf-23 and vascular calcification in a peritoneal dialysis population with resi...
Santos,Sofia; Oliveira,José Carlos; Barra,Tiago; Campos,Andreia; Carvalho,Maria João; Malheiro,Jorge; Fonseca,Isabel; Cabrita,António; Adragão,TeresaIntroduction and Aims: Fibroblast growth factor 23 (FGF-23) induces phosphaturia. Its clinical impact is beyond mineral bone disease in chronic kidney disease (CKD), being coupled with vascular calcification and mortality. Residual renal function (RRF) is associated with significant capacity to excrete phosphate in peri- toneal dialysis (PD). Besides testing whether FGF-23 is still related with glomerular filtr...
Acute rejection during the first six-months after transplantation: temporal tre...
Costa,Rui; Malheiro,Jorge; Santos,Clara; Fonseca,Isabel; Martins,La Salete; Pedroso,Sofia; Almeida,Manuela; Dias,Leonidio; Castro-Henriques,AntonioObjective: To determine risk factors for acute rejection in the first 6 months post- transplant and their effect on death-censored graft and patient survival in the 990-1999 and 2000-2009 periods. Patients and Methods: Retrospective analysis of acute rejection episodes was performed separately in two periods: 1990-1999 and 2000-2009. Multivariate logistic regression analysis was performed in order to identify r...
Biomarkers in Kidney Transplantation: Translating to clinical practice
Fonseca,IsabelImproving long-term graft survival is a major challenge in kidney transplantation. Ischaemia-reperfusion injury is a critical early allograft insult that enhances the risk of delayed graft function, which is common in deceased-donor transplantation. Delayed graft function complicates the post-transplant management and has a negative impact on both short and long-term outcomes. The development of effective inter...
Pancreas-Kidney Transplantation: Analysis of 150 patients from one Centre in Po...
Martins,La Salete; Fonseca,Isabel; Aguiar,Pedro; Rocha,Ana; Costa,Rui; Santos,Clara; Malheiro,Jorge; Pedroso,Sofia; Almeida,Manuela; Dias,LeonidioIntroduction: Simultaneous pancreas-kidney transplantation (SPKT) outcomes are conditioned in the short-term mostly by post-operative complications. In the long-term, cardiovascular (CV) disease and immunological loss are the main limitations to transplant survival. Aims: To analyse retrospectively the results from 150 SPKT performed at our centre. Patients and Methods: The 81 females and 69 males had a mean ag...