6 documents found, page 1 of 1
Induction of apoptosis in HuH-7 cancer cells by monoterpene and beta-carboline ...
Mansoor, Tayyab A.; Ramalho, Rita M.; Mulhovo, Silva; Rodrigues, Cecilia M. P.; Ferreira, Maria Jose U.Three known (1-3) and a novel (4) monoterpene indole alkaloids have been isolated from the methanol extract of leaves of Tabernaemontana elegans and their structures were elucidated by a series of spectroscopic experiments, involving NMR, MS, UV, and IR techniques. The isolated monoterpene indole alkaloids along with previously described beta-carbolines (5-7) from the same specimen were studied for their apopto...
Bile acids and apoptosis modulation
Ramalho, Rita M.; Viana, Ricardo J. S.; Low, Walter C.; Steer, Clifford J.; Rodrigues, Cecilia M. P.The potential role of apoptosis in Alzheimer's disease (AD) has been an area of intense research in recent years. Ursodeoxycholic acid (UDCA) and its taurine-conjugate, tauroursodeoxycholic acid (TUDCA) are endogenous bile acids that act as potent inhibitors of apoptosis. Their therapeutic effects have been tested in many experimental pathological conditions, including neurological disorders, such as AD. TUDCA ...
Apoptosis in Transgenic mice expressing the P301L mutated form of human tau
Ramalho, Rita M.; Viana, Ricardo J. S.; Castro, Rui E.; Steer, Clifford J.; Low, Walter C.; Rodrigues, Cecilia M. P.The rTg4510 mouse is a tauopathy model, characterized by massive neurodegeneration in Alzheimer's disease (AD)-relevant cortical and limbic structures, deficits in spatial reference memory, and progression of neurofibrillary tangles (NFT). In this study, we examined the role of apoptosis in neuronal loss and associated tau pathology. The results showed that DNA fragmentation and caspase-3 activation are common ...
Functional modulation of nuclear steroid receptors by tauroursodeoxycholic acid...
Sola, Susana; Amaral, Joana D.; Borralho, Pedro M.; Ramalho, Rita M.; Castro, Rui E.; Aranha, Marcia M.; Steer, Cifford J.; Rodrigues, Cecilia M. P.Tauroursodeoxycholic acid ( TUDCA) prevents amyloid beta-peptide (A beta)-induced neuronal apoptosis, by modulating both classical mitochondrial pathways and specific upstream targets. In addition, activation of nuclear steroid receptors (NSRs), such as t
Apoptosis and Bcl-2 expression in the livers of patients with steatohepatitis
Ramalho, Rita M.; Cortez-Pinto, Helena; Castro, Rui E.; Sola, Susana; Costa, Adilia; Moura, Miguel C.; Camilo, Maria E.; Rodrigues, Cecilia M. P.Objectives. Apoptosis may play a role in the pathogenesis of alcoholic (ASH) and non-alcoholic steatolhepatitis (NASH). In this study, we investigated the modulation of apoptosis-related liver proteins in steatohepatitis. Methods. Hepatocyte apoptosis was
Tauroursodeoxycholic acid modulates p53-mediated apoptosis in Alzheimer's disea...
Ramalho, Rita M.; Borralho, Pedro M.; Castro, Rui E.; Sola, Susana; Steer, Clifford J.; Rodrigues, Cecilia M. P.Early onset familial Alzheimer's disease (FAD) is linked to autosomal dominant mutations in the amyloid precursor protein (APP) and presenilin 1 and 2 (PS1 and PS2) genes. These are critical mediators of total amyloid beta-peptide (A beta) production, ind