55 documents found, page 1 of 6
COVID-19 e DPOC: qual o impacto nos indicadores dos cuidados de saúde primários...
Pinto Ferreira, Clara; Vicente, Cláudia; Castro, Daniel; Silva, Eurico; Mendes, Guilherme; Ramires, João; Alves, Luís; Cruz, MargaridaIntrodução: A pandemia COVID-19 trouxe desafios e dificuldades que impactaram o sistema de saúde, nomeadamente a gestão e o diagnóstico da doença pulmonar obstrutiva crónica (DPOC) nos cuidados de saúde primários (CSP). Objetivos: Refletir sobre o impacto da pandemia da COVID-19 na gestão da DPOC nos CSP. Métodos: Analisaram-se os indicadores de DPOC disponíveis publicamente entre Dez/2018 e Fev/2020 (pré-pande...
Synergistic effect of aloe vera hydrogels with imatinib for pH-responsive drug ...
Khan, Aroob Hasan; Shehzad, Adeeb; Pirela, Paola; Atalaia, Mariana; Ruivinho, Beatriz Lourenço; Rashan, Luay; Miran, Waheed; Duarte, Sofia O. D.Imatinib (IM) efficacy as a cancer drug is limited by pharmacokinetic drug resistance developed during systemic circulation before reaching the target site.Hydrogels have attracted attention because of their characteristic physiochemical and biochemical properties, flexibility, and the ability to release drugs directly at target sites causing cancer mitigation. The current study aims at developing Aloe Vera (AV...
Nanomedicine in oncology: diagnostic breakthroughs and therapeutic Frontiers
Shehzad, Adeeb; Alves, Júlia; Ul-Islam, Mazhar; Saidi, Abdullah Khamis Al; Duarte, Sofia O. D.; Khan, Mohammad Sherjeel Javed; Fonte, PedroNanomedicine is a multidisciplinary field, offering significant promises for cancer detection and therapy. Nanoparticles (NPs), nanoprobes and nanobiosensors can be tailored to achieve highly sensitive tumor detection by contrast imaging techniques. The application of directed drug delivery for cancer therapies can be achieved via the formulation and tailoring of drug-loaded nanocarriers. NPs have been employed...
Inhalable N-acetylcysteine-loaded lactose-coated PLGA nanoparticles for tubercu...
Chaudhary, Kabi Raj; Mestre Viegas, Cláudia Sofia; Pirela, Paola; Atalaia, Mariana; Ruivinho, Beatriz Lourenço; Arora, Sanchit; Singh, ArtiObjective Glutathione (GSH), known for having mucolytic, anti-inflammatory, and antioxidant activities, is used in clinical practice in several pathologies, including tuberculosis (TB). N-acetylcysteine (NAC) has been primarily used to treat lung conditions and paracetamol-induced liver toxicity. However, NAC exhibits potential antimycobacterial activity through several mechanisms including immunomodulation, en...
Transforming cancer treatment: the potential of nanonutraceuticals
Kumar, Girish; Virmani, Tarun; Chhabra, Vaishnavi; Virmani, Reshu; Pathak, Kamla; Akhtar, Md Sayeed; Asim, Mulazim Hussain; Arshad, ShumailaChemotherapy in the management of cancer is constrained by limitations like off-target effects, poor bioavailability, and dose-dependent toxicity. Nutraceuticals have been explored as an innovative strategy to overcome chemotherapy drawbacks. However, the clinical utility of nutraceuticals is restricted due to their complex structures, less water solubility, reduced stability, decreased bioavailability and more...
Camptothecin-loaded mesoporous silica nanoparticles functionalized with CpG oli...
Qureshi, Munibah; Viegas, Cláudia; Duarte, Sofia O.D.; Girardi, Michael; Shehzad, Adeeb; Fonte, PedroThe therapeutic efficacy of camptothecin (CPT), a potent antitumor alkaloid, is hindered by its hydrophobic nature and instability, limiting its clinical use in treating cutaneous squamous cell carcinoma (SCC). This study introduces a novel nano drug delivery system (NDDS) utilizing functionalized mesoporous silica nanoparticles (FMSNs) for efficient CPT delivery. The FMSNs were loaded with CPT and subsequently...
Lipid-based nanoformulations for drug delivery: an ongoing perspective
Rehman, Mubashar; Tahir, Nayab; Sohail, Muhammad Farhan; Qadri, Muhammad Usman; Duarte, Sofia O. D.; Brandão, Pedro; Esteves, Teresa; Javed, IbrahimOils and lipids help make water-insoluble drugs soluble by dispersing them in an aqueous medium with the help of a surfactant and enabling their absorption across the gut barrier. The emergence of microemulsions (thermodynamically stable), nanoemulsions (kinetically stable), and self-emulsifying drug delivery systems added unique characteristics that make them suitable for prolonged storage and controlled relea...
Impact of the use of cryoprotectants in the production of freeze-dried soluble ...
Barroso, Livia Alves; Viegas, Cláudia; Stančiauskaitė, Monika; Macedo, Ana S.; Lemos, Iara Lopes; da Costa, Joyce Maria Gomes; Schmiele, MarcioCold brew is a method of coffee extraction that uses low temperature, preserving the volatile compounds of coffee. Freeze-drying allows the preservation of coffee features and nutritional value. The aim of this study was to evaluate the effects of different cryoprotectants in cold brew extracts as a basis for freeze-dried coffee production. Thus, the Coffea arabica extracts and the soluble coffee were character...
Sustainable carbon dots loaded into carboxymethylcellulose based hydrogels for ...
Rodrigues, Jordane S.; Brandão, Pedro; Duarte, Sofia O. D.; Silveira, Izabela Boueri da; Leite, Maria de Fátima; Gonçalves, Max P.Abstract: Background/Objectives: The development of innovative materials for disease diagnostics and therapeutics is a fast-growing area of scientific research. In this work, we report the development of innovative hydrogels incorporating carbon dots (Cdots) for bioimaging purposes. Methods: The Cdots were prepared using a sustainable and low-cost process, starting with an underused fiber from the Brazilian sem...
Impact of the use of cryoprotectants in the production of freeze-dried soluble ...
Barroso, Livia Alves; Viegas, Cláudia; Stančiauskaitė, Monika; Macedo, Ana S.; Lemos, Iara Lopes; Costa, Joyce Maria Gomes da; Schmiele, MarcioCold brew is a method of coffee extraction that uses low temperature, preserving the volatile compounds of coffee. Freeze-drying allows the preservation of coffee features and nutritional value. The aim of this study was to evaluate the effects of different cryoprotectants in cold brew extracts as a basis for freeze-dried coffee production. Thus, the Coffea arabica extracts and the soluble coffee were character...