49 documents found, page 1 of 5

COVID-19 e DPOC: qual o impacto nos indicadores dos cuidados de saúde primários...

Introdução: A pandemia COVID-19 trouxe desafios e dificuldades que impactaram o sistema de saúde, nomeadamente a gestão e o diagnóstico da doença pulmonar obstrutiva crónica (DPOC) nos cuidados de saúde primários (CSP). Objetivos: Refletir sobre o impacto da pandemia da COVID-19 na gestão da DPOC nos CSP. Métodos: Analisaram-se os indicadores de DPOC disponíveis publicamente entre Dez/2018 e Fev/2020 (pré-pande...

Synergistic effect of aloe vera hydrogels with imatinib for pH-responsive drug ...

Imatinib (IM) efficacy as a cancer drug is limited by pharmacokinetic drug resistance developed during systemic circulation before reaching the target site.Hydrogels have attracted attention because of their characteristic physiochemical and biochemical properties, flexibility, and the ability to release drugs directly at target sites causing cancer mitigation. The current study aims at developing Aloe Vera (AV...

Nanomedicine in oncology: diagnostic breakthroughs and therapeutic Frontiers

Nanomedicine is a multidisciplinary field, offering significant promises for cancer detection and therapy. Nanoparticles (NPs), nanoprobes and nanobiosensors can be tailored to achieve highly sensitive tumor detection by contrast imaging techniques. The application of directed drug delivery for cancer therapies can be achieved via the formulation and tailoring of drug-loaded nanocarriers. NPs have been employed...

Transforming cancer treatment: the potential of nanonutraceuticals

Chemotherapy in the management of cancer is constrained by limitations like off-target effects, poor bioavailability, and dose-dependent toxicity. Nutraceuticals have been explored as an innovative strategy to overcome chemotherapy drawbacks. However, the clinical utility of nutraceuticals is restricted due to their complex structures, less water solubility, reduced stability, decreased bioavailability and more...

Camptothecin-loaded mesoporous silica nanoparticles functionalized with CpG oli...

The therapeutic efficacy of camptothecin (CPT), a potent antitumor alkaloid, is hindered by its hydrophobic nature and instability, limiting its clinical use in treating cutaneous squamous cell carcinoma (SCC). This study introduces a novel nano drug delivery system (NDDS) utilizing functionalized mesoporous silica nanoparticles (FMSNs) for efficient CPT delivery. The FMSNs were loaded with CPT and subsequently...

Lipid-based nanoformulations for drug delivery: an ongoing perspective

Oils and lipids help make water-insoluble drugs soluble by dispersing them in an aqueous medium with the help of a surfactant and enabling their absorption across the gut barrier. The emergence of microemulsions (thermodynamically stable), nanoemulsions (kinetically stable), and self-emulsifying drug delivery systems added unique characteristics that make them suitable for prolonged storage and controlled relea...

Impact of the use of cryoprotectants in the production of freeze-dried soluble ...

Cold brew is a method of coffee extraction that uses low temperature, preserving the volatile compounds of coffee. Freeze-drying allows the preservation of coffee features and nutritional value. The aim of this study was to evaluate the effects of different cryoprotectants in cold brew extracts as a basis for freeze-dried coffee production. Thus, the Coffea arabica extracts and the soluble coffee were character...

Gestão e seguimento do doente com DPOC

Vacinação do doente com DPOC

Nanocarriers in Tuberculosis Treatment: Challenges and Delivery Strategies

The World Health Organization identifies tuberculosis (TB), caused by Mycobacterium tuberculosis, as a leading infectious killer. Although conventional treatments for TB exist, they come with challenges such as a heavy pill regimen, prolonged treatment duration, and a strict schedule, leading to multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains. The rise of MDR strains endangers future TB c...