2 documents found, page 1 of 1
Health status and COVID-19 epidemiology in an inland region of Portugal: A retr...
Lindo, Jorge; Coelho, Patrícia; Gavinhos, Catarina; Martins, Manuel; Liberal, Joana; Ferreira, António Jorge; Gonçalves, Teresa O.; Rodrigues, FranciscoMultiple factors, from socioeconomic development to genetic background, can affect the regional impact of some diseases, and this has also been seen during the COVID-19 pandemic. The objective of this retrospective study was to characterize a population in the interior of Portugal regarding health status and COVID-19 epidemiology. Between October 2021 and January 2023, 1553 subjects residing in Beira Baixa, Por...
Genetic polymorphisms of P2RX7 but not of ADORA2A are associated with the sever...
Lindo, Jorge; Nogueira, Célia; Soares, Rui; Cunha, Nuno; Almeida, Maria Rosário; Rodrigues, Lisa; Coelho, Patrícia; Rodrigues, FranciscoSARS-CoV-2 infection ranges from mild to severe presentations, according to the intensity of the aberrant inflammatory response. Purinergic receptors dually control the inflammatory response: while adenosine A2A receptors (A2ARs) are anti-inflammatory, ATP P2X7 receptors (P2X7Rs) exert pro-inflammatory effects. The aim of this study was to assess if there were differences in allelic and genotypic frequencies of...