4 documents found, page 1 of 1
Oncobiology and treatment of breast cancer in young women
Kumar, Rakesh; Marques, Catarina; Toi, Masakazu; Saini, Sunil; Casimiro, Sandra; Arora, Anshika; Paul, Aswathy Mary; Velaga, Ravi; Rameshwar, PranelaFemale breast cancer emerged as the leading cancer type in terms of incidence globally in 2020. Although mortality due to breast cancer has improved during the past three decades in many countries, this trend has reversed in women less than 40 years since the past decade. From the biological standpoint, there is consensus among experts regarding the clinically relevant definition of breast cancer in young women...
Impact of extraskeletal metastases on skeletal-related events in metastatic cas...
Lobo-Martins, Soraia; Ferreira, Arlindo; Mansinho, André; Casimiro, Sandra; Leitzel, Kim; Ali, Suhail; Lipton, Allan; Costa, LuisThe therapeutic landscape of metastatic castration-resistant prostate cancer (mCRPC) has substantially evolved over the last decade. Nonetheless, a better understanding of bone-targeted agents (BTAs) action in mCRPC remains an unmet need. Theuse of BTAs aims to reduce the incidence of skeletal-related events (SREs) in patients with mCRPC. Less frequent BTA schedules are currently being studied to minimize adver...
N-Telopeptide of Type I collagen long-term dynamics in breast cancer patients w...
Ferreira, Arlindo; Alho, Irina; Shan, Ning; Matias, Margarida; Faria, Mariana; Casimiro, Sandra; Leitzel, Kim; Ali, Suhail; Lipton, Allan; Costa, LuisBackground: Markers of bone metabolism, such as N-telopeptide of type I collagen (NTX), have been demonstrated to be prognostic in previous trials of breast cancer (BC) patients with bone metastases (BMs). In the present study, we tested the survival effect of the NTX response to zoledronic acid (ZA) at 3 and 12 months in a contemporaneous cohort of BC patients with BMs and evaluated the influence of extraskele...
RANKL/RANK/MMP-1 molecular triad contributes to the metastatic phenotype of bre...
Casimiro, Sandra; Mohammad, Khalid S.; Pires, Ricardo; Tato-Costa, Joana; Alho, Irina; Teixeira, Rui Lourenço; Carvalho, António; Ribeiro, SofiaThe osteolytic nature of bone metastasis results from a tumor-driven increased bone resorption. Bone remodeling is orchestrated by the molecular triad RANK-RANKL-OPG. This process is dysregulated in bone metastases, mostly via induction of RANKL by tumor-derived factors. These factors increase expression of RANKL, which induce osteoclast formation, function, and survival, thereby increasing bone resorption. RAN...