25 documents found, page 1 of 3
Crystallization and preliminary X-ray diffraction studies of BnSP-6, a myotoxic...
Fontes, Marcos R. M. [UNESP]; Monteiro, Luiz E. [UNESP]; Soares, Andreimar M.; Rodrigues, Veridiana M.; Da Silva, Reinaldo J. [UNESP]; Giglio, José R.Made available in DSpace on 2022-04-28T19:56:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2000-12-01; BnSP-6 (myotoxin I) is a phospholipase A2 homologue isolated from Bothrops neuwiedi pauloensis venom. Crystals of BnSP-6 were obtained which diffracted X-rays to 2.5 Å resolution using a synchrotron radiation source at room temperature and belong to space group P3121. The unit cell dimensions are a=b=57...
Inflammasome NLRP3 activation induced by Convulxin, a C-type lectin-like isolat...
Rego, Cristina M. A.; Francisco, Aleff F. [UNESP]; Boeno, Charles N.; Paloschi, Mauro V.; Lopes, Jéssica A.; Silva, Milena D. S.; Santana, Hallison M.Made available in DSpace on 2022-04-28T19:52:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-12-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Convulxin (CVX), a C-type lectin-like protein isolated from the venom of the snake species, Crotalus d...
Mitochondrial Sirtuin TcSir2rp3 Affects TcSODA Activity and Oxidative Stress Re...
dos Santos Moura, Leila; Santana Nunes, Vinícius; Gomes, Antoniel A. S. [UNESP]; Sousa, Ana Caroline de Castro Nascimento; Fontes, Marcos R. M. [UNESP]Made available in DSpace on 2022-04-29T08:46:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-11-11; Trypanosoma cruzi faces a variety of environmental scenarios during its life cycle, which include changes in the redox environment that requires a fine regulation of a complex antioxidant arsenal of enzymes. Reversible posttranslational modifications, as lysine acetylation, are a fast and economical way...
The intriguing phospholipases A2 homologues: Relevant structural features on my...
Santos, Juliana I. Dos [UNESP]; Fernandes, Carlos A. H. [UNESP]; Magro, Angelo J. [UNESP]; Fontes, Marcos R. M. [UNESP]Made available in DSpace on 2022-04-28T20:54:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-08-01; Phospholipases A2 homologues are found in the venom of Crotalinae snakes, being their main action related to myonecrosis induction. Although many studies on these toxins had already been performed, their mechanism of action remains unclear. Here, important aspects about these toxins are reviewed, includ...
Influence of quaternary conformation on the biological activities of the Asp49-...
Magro, Angelo J. [UNESP]; Fernandes, Carlos A. H. [UNESP]; Santos, Juliana I. Dos [UNESP]; Fontes, Marcos R. M. [UNESP]Made available in DSpace on 2022-04-28T20:54:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-08-01; One of the main components of snake venoms are the Asp49-phospholipases A2, also known as svPLA2s. The study of these toxins is a matter of great scientific interest due to their wide variety of biological effects. In this work we present strong evidences found in literature and other aspects which stre...
Structure of importin-α from a filamentous fungus in complex with a classical n...
Bernardes, Natalia E. [UNESP]; Takeda, Agnes A. S. [UNESP]; Dreyer, Thiago R. [UNESP]; Freitas, Fernanda Z. [UNESP]; Bertolini, Maria Célia [UNESP]Made available in DSpace on 2022-04-29T07:26:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-06-19; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Neurospora crassa is a filamentous fungus that has been extensively studied as a model organism for eukaryotic biology, providing fundamental insights into cellular ...
The allosteric activation mechanism of a phospholipase A2-like toxin from Bothr...
Gomes, Antoniel A. S. [UNESP]; Cardoso, Fabio F. [UNESP]; Souza, Maximilia F.; Oliveira, Cristiano L. P.; Perahia, David; Magro, Angelo J. [UNESP]Made available in DSpace on 2021-06-25T10:12:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-12-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); The activation process of phospholipase A2-like (PLA2-like) toxins is a key step in their molecular mechanism, which involves oligomeric changes leading to the expos...
Comparative study of the interactions between fungal transcription factor nucle...
Bernardes, Natália E. [UNESP]; Fukuda, Cintia A. [UNESP]; da Silva, Tainá D. [UNESP]; de Oliveira, Hamine C. [UNESP]; de Barros, Andrea C. [UNESP]Made available in DSpace on 2020-12-12T01:55:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-12-01; Importin-α (Impα) is an adaptor protein that binds to cargo proteins (containing Nuclear Localization Sequences - NLSs), for their translocation to the nucleus. The specificities of the Impα/NLS interactions have been studied, since these features could be used as important tools to find potential NLSs ...
Structural basis for phospholipase A2-like toxin inhibition by the synthetic co...
Salvador, Guilherme H. M. [UNESP]; Gomes, Antoniel A. S. [UNESP]; Bryan-Quirós, Wendy; Fernández, Julián; Lewin, Matthew R.; Gutiérrez, José MaríaMade available in DSpace on 2020-12-12T01:05:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-12-01; The World Health Organization recently listed snakebite envenoming as a Neglected Tropical Disease, proposing strategies to significantly reduce the global burden of this complex pathology by 2030. In this context, effective adjuvant treatments to complement conventional antivenom therapy based on inhib...
Search for efficient inhibitors of myotoxic activity induced by ophidian phosph...
Salvador, Guilherme H. M. [UNESP]; Cardoso, Fábio Florença [UNESP]; Gomes, Antoniel A. [UNESP]; Cavalcante, Walter L. G. [UNESP]Made available in DSpace on 2019-10-06T17:01:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-12-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Ophidian accidents are considered an important neglected tropical disease by the World Health Organization. Particularly in Latin America, Bothrops snakes are responsible for the majority of the snakebite envenomings that are not efficiently...