14 documents found, page 1 of 2
Association of thyroid function, within the euthyroid range, with cardiovascula...
Neves, JS; Fontes-Carvalho, R; Borges-Canha, M; Leite, AR; von Hafe, M; Vale, C; Martins, S; Guimarães, JT; Carvalho, D; Leite-Moreira, A; Azevedo, ABackground: Thyroid hormones are important modulators of cardiovascular function. Both hypothyroidism and hyperthyroidism are known to contribute to an increased cardiovascular risk. It remains uncertain whether thyroid hormones level within the euthyroid range are associated with cardiometabolic risk. We aimed to evaluate the association between thyroid function levels within the euthyroid range and cardiovasc...
Thyroid Hormones within the Normal Range and Cardiac Function in the General Po...
Neves, JS; Fontes-Carvalho, R; Borges-Canha, M; Leite, AR; Martins, S; Oliveira, A; Guimarães, JT; Carvalho, D; Leite-Moreira, A; Azevedo, ABackground: Hypothyroidism and hyperthyroidism are associated with marked changes in cardiac structure and function. However, the association of thyroid function within the normal range with cardiac structure and function in the general population remains uncertain. Methods: Eight hundred thirty-five subjects aged ≥45 years from the EPIPorto cohort (evaluation between 2006 and 2008) were cross-sectionally analy...
Metabolic syndrome severity score is associated with diastolic dysfunction and ...
Ladeiras-Lopes, R; Teixeira, P; Azevedo, A; Leite-Moreira, A; Bettencourt, N; Fontes-Carvalho, RMetabolic syndrome (MetS) affects approximately one out of three adults in western countries and it combines a cluster of cardiovascular risk factors. A continuous gender and race/ethnicity-specific MetS severity score was recently described and validated, and is an independent predictor of cardiovascular events, beyond individual MetS components. We aimed to assess if this score was associated with subclinical...
Practical Guide for the Use of PCSK9 Inhibitors in Portugal
Fontes-Carvalho, R; Marques da Silva, P; Rodrigues, E; Araújo, F; Gavina, C; Ferreira, J; Morais, JReducing low-density lipoprotein cholesterol (LDL-C) levels is one of the most important strategies for reducing the risk of cardiovascular events. However, in clinical practice, a high proportion of patients do not achieve recommended LDL-C levels through lifestyle and lipid-lowering therapy with statins and ezetimibe. PCSK9 inhibitors (PCSK9i) are a new therapeutic option that significantly (50-60%) reduces L...
New Prospects for the Management of Cardiovascular Effects of Tyrosine Kinase I...
Almeida, A; Almeida, A; Melo, T; Guerra, L; Lopes, L; Ribeiro, P; Duarte, M; Mota, A; Fontes-Carvalho, RThe use of tyrosine kinase inhibitors (TKIs) for the treatment of chronic myeloid leukemia has significantly altered the prognosis of this disease, enabling close to normal life expectancy. Despite their undeniable benefits, the use of TKIs is associated with an increased risk of side effects on the cardiovascular system, particularly of atherothrombotic events. It is therefore necessary to understand and preve...
Meta-Analysis of Relation of Epicardial Adipose Tissue Volume to Left Atrial Di...
Mancio, J; Azevedo, D; Fragão-Marques, M; Falcão-Pires, I; Leite-Moreira, A; Lunet, N; Fontes-Carvalho, R; Bettencourt, NMany studies have explored the hypothesis that epicardial adipose tissue (EAT) accumulation adversely affects cardiac remodeling. We assessed, through a systematic review and meta-analysis, whether EAT is linked to left atrial (LA) and left ventricular (LV) structure and function, irrespective of global or abdominal visceral adiposity. We searched MEDLINE, Scopus, and Web of Science for studies evaluating the a...
Left atrial deformation analysis by speckle tracking echocardiography to predic...
Fontes-Carvalho, R; Sampaio, F; Teixeira, M; Ruivo, C; Ribeiro, J; Azevedo, A; Leite-Moreira, A; Ribeiro, VGIntroduction: Left atrial (LA) size and function are associated with outcome after myocardial infarction (MI). In this study we aimed to assess the impact of LA function as a predictor of exercise capacity through speckle tracking echocardiography. Methods: A total of 94 patients (mean age 54.8 +/- 11.0 years; 82% male) were enrolled one month after MI. Echocardiography was used to assess LA volumes and various...
Impact of the 2016 ASE/EACVI recommendations on the prevalence of diastolic dys...
Almeida, JG; Fontes-Carvalho, R; Sampaio, F; Ribeiro, J; Bettencourt, P; Flachskampf, FA; Leite-Moreira, A; Azevedo, AAims: Diastolic dysfunction (DD) is frequent in the general population; however, the assessment of diastolic function remains challenging. We aimed to evaluate the impact of the recent 2016 American Society of Echocardiography (ASE)/European Association of Cardiovascular Imaging (EACVI) recommendations in the prevalence and grades of DD compared with the 2009 guidelines and the Canberra Study Criteria (CSC). Me...
Diastolic Function Is Impaired in Patients With Prehypertension: Data From the ...
Ladeira-Lopes, R; Fontes-Carvalho, R; Vilela, EM; Bettencourt, P; Moreira, A; Azevedo, AIntroduction and objectives: Hypertension causes subclinical changes in left ventricular structure and function, namely diastolic dysfunction. Diastolic dysfunction is a predictor of heart failure, being involved in the association between hypertension and heart failure with preserved ejection fraction. We aimed to determine whether patients with prehypertension have early changes in diastolic function in a lar...
Direct, inflammation-mediated and blood-pressure-mediated effects of total and ...
Fontes-Carvalho, R; Gonçalves, A; Severo, M; Lourenço, P; Rocha-Gonçalves, F; Bettencourt, P; Leite-Moreira, A; Azevedo, ABackground: Obesity has been associated with subclinical diastolic dysfunction and increased risk of heart failure. Our aims were to evaluate the age- and sex-specific role of total and abdominal adiposity on diastolic function and to assess the direct and indirect pathophysiological mechanisms involved in this association. Methods and results: Within a population-based study (EPIPorto), a total of 1063 individ...