2 documents found, page 1 of 1
Adenosine A(2A) receptor blockade reverts hippocampal stress-induced deficits a...
Batalha, V. L.; Pêgo, José M.; Fontinha, B. M.; Costenla, A. R.; Valadas, J. S.; Baqi, Y.; Radjainia, H.; Müller, C. E.; Sebastião, A. M.; Lopes, L. V.Maternal separation (MS) is an early life stress model that induces permanent changes in the central nervous system, impairing hippocampal long-term potentiation (LTP) and spatial working memory. There are compelling evidences for a role of hippocampal adenosine A(2A) receptors in stress-induced modifications related to cognition, thus opening a potential window for therapeutic intervention. Here, we submitted ...
Tonic adenosine A1 and A2A receptor activation is required for the excitatory a...
Cunha-Reis, Diana; Fontinha, B. M.; Ribeiro, Joaquim A.; Sebastião, Ana MAdenosine can regulate synaptic transmission through modulation of the action of other neurotransmitters. The influence of adenosine on VIP enhancement of synaptic transmission in hippocampal slices was investigated. Facilitation of fEPSP slope by 1 nM VIP (23.3 ± 1.3%) was turned into an inhibition (-12.1 ± 3.4%) when extracellular endogenous adenosine was removed using adenosine deaminase (ADA, 1 U/ml). Block...